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GlossaryTRPV3

protein channel involved in skin and hair follicle function

TRPV3 is a protein that functions as an ion channel in the cell membranes of skin and hair follicle cells. It plays a crucial role in sensing temperature and chemical stimuli, and its proper function is essential for maintaining healthy skin and hair growth. Mutations in the TRPV3 gene can lead to skin disorders and hair loss conditions, making it a significant focus in dermatological and trichological research.

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research TRPV3 as a Therapeutic Target for Itch

88 citations, April 2012 in “Journal of Investigative Dermatology”

Blocking TRPV3 may help treat itch in dry skin conditions.

research Activation of TRPV3 Regulates Inflammatory Actions of Human Epidermal Keratinocytes

77 citations, September 2017 in “Journal of Investigative Dermatology”

TRPV3 in skin cells causes inflammation and cell death.

research Influence of TRPV3 Mutation on Hair Growth Cycle in Mice

59 citations, September 2007 in “Biochemical and Biophysical Research Communications”

The TRPV3 gene mutation affects hair growth by keeping mice in the growth phase longer, which could help treat hair loss.

research Structural Mechanism of TRPV3 Channel Inhibition by the Plant-Derived Coumarin Osthole

28 citations, September 2021 in “EMBO reports”

Osthole inhibits the TRPV3 channel by binding to specific sites, potentially aiding drug development for skin diseases and cancers.

research Activation of TRPV3 Inhibits Lipogenesis and Stimulates Production of Inflammatory Mediators in Human Sebocytes—A Putative Contributor to Dry Skin Dermatoses

26 citations, August 2018 in “Journal of Investigative Dermatology”

Activating TRPV3 reduces skin oil production and increases inflammation, potentially causing dry skin issues.

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community Progress pictures. 2 months on Fin, 4 on Min.

in Progress Pictures 191 upvotes 1 month ago

The user experienced significant hair regrowth after using Finasteride for 2 months and Minoxidil for 4 months, along with a derma roller. They reported no side effects from the treatments and noted that Finasteride seemed to contribute most to the progress.