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    GlossaryTransient Receptor Potential Vanilloid 1

    protein channel that detects heat, acidity, and capsaicin

    Transient Receptor Potential Vanilloid 1 (TRPV1), also known as the Capsaicin Receptor, is a protein found on the surface of certain cells, including sensory neurons. It acts as an ion channel that opens in response to heat, acidic conditions, and capsaicin (the compound that makes chili peppers hot), playing a crucial role in the sensation of pain and temperature.

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      community Physician here AMA – 30M oral Fin 1-1.25 mg daily

      in Update  47 upvotes   2 years ago
      Hair loss treatments, specifically the use of finasteride, microneedling and potentially oral minoxidil. People discussed their experiences with finasteride, its effects on sexual behaviors, as well as potential solutions such as tadalafil or using other growth factor signal peptides for hope in curing male pattern baldness.

      community Creatine's effect on Hair Loss and DHT

      in Research/Science  99 upvotes   5 months ago
      A 21-year-old male managed to control his hair loss using Nizoral, RU58841, and finasteride, but experienced increased scalp itchiness after starting creatine, which subsided upon stopping creatine. Users shared mixed experiences on whether creatine affects hair loss, with some reporting negative effects and others seeing no change or defending its benefits.

      community Pyrilutamide just launched internationally, and all you're doing is hating

      in Product   1 day ago
      The post and conversation are about the high cost and skepticism surrounding pyrilutamide as a hair loss treatment, with comparisons to minoxidil, finasteride, and RU58841. The original poster defends pyrilutamide's effectiveness and criticizes others for dismissing it without proper understanding.

      community GT20029 China Phase II Trial For AGA Reached Primary Endpoint

      in Research/Science  131 upvotes   3 months ago
      The GT20029 tincture, a topical androgen receptor degrader, showed significant hair growth and good safety in a China Phase II trial for male androgenetic alopecia (AGA), with the 1% dose twice weekly identified as optimal. The company plans to initiate Phase III trials in China and Phase II in the U.S., and the treatment also shows promise for acne.