research Localization of mechanosensitive channel TRPV4 in mouse skin
In this study, TRPV4 channels were found in specific mechanosensory endings in mice skin, suggesting a role in pressure sensation transmitted through A- and C-fibers.
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5 / 469 resultsresearch TRPV3 as a Therapeutic Target for Itch
This study suggests that TRPV3 may play a key role in dry skin-related itch, indicating potential for TRPV3 antagonists in treating pruritus resistant to histamine H1R antagonists.
research Activation of TRPV3 Regulates Inflammatory Actions of Human Epidermal Keratinocytes
This study found that TRPV3 ion channels on human epidermal keratinocytes suppress cell proliferation, induce cell death, and trigger a proinflammatory response, suggesting a role in cutaneous inflammatory processes.
research Influence of TRPV3 mutation on hair growth cycle in mice
This study found that a gain-of-function mutation in the TRPV3 channel leads to altered hair development in DS-Nh mice by affecting the anagen and telogen phases, highlighting TRPV3's role in hair growth regulation.
research Structural mechanism of TRPV3 channel inhibition by the plant‐derived coumarin osthole
In this study, researchers used cryo-electron microscopy to reveal how the natural compound osthole inhibits TRPV3 channels by binding to specific sites, changing the channel's conformation.
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