TRP Channels in Skin Biology and Pathophysiology
December 2016
in “
Pharmaceuticals
”
TLDR TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.
Transient Receptor Potential (TRP) channels in the skin mediated the influx of cations in response to various stimuli and were expressed in cell types like keratinocytes, sensory neurons, melanocytes, and immune cells. They played roles in sensation and skin homeostasis. Abnormal TRP channel function was linked to skin conditions such as chronic pain, itch, dermatitis, vitiligo, alopecia, wound healing issues, skin cancer, and barrier compromise. Their diverse functions and pharmacologically accessible sites made TRP channels promising therapeutic targets for skin disorders.
