Dermal TRPV1 Innervations Engage a Macrophage- and Fibroblast-Containing Pathway to Activate Hair Growth in Mice

    June 2024 in “ Developmental Cell ”
    Tamar L. Ben-Shaanan, Konrad Knöpper, Lihui Duan … Jason G. Cyster
    Studysummary In this study, activating TRPV1 nociceptors in mice skin stimulated dormant hair follicles and promoted hair growth through a mechanism involving dermal macrophages, fibroblasts, and neuropeptides, highlighting a new role for nociceptors in tissue recovery after injury.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on cell.com →
    Discuss this study in the Community →

    Research cited in this study 14

    1. Signaling by Senescent Melanocytes Hyperactivates Hair Growth Nature · 2023
    2. Hedgehog Signaling Reprograms Hair Follicle Niche Fibroblasts to a Hyper-Activated State Developmental cell · 2022
    3. Dissecting the Microenvironment Around Biosynthetic Scaffolds in Murine Skin Wound Healing Science Advances · 2021
    4. Corticosterone Inhibits GAS6 to Govern Hair Follicle Stem-Cell Quiescence Nature · 2021
    5. Hyperactivation of Sympathetic Nerves Drives Depletion of Melanocyte Stem Cells Nature · 2020
    6. A Subset of TREM2+ Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth Cell Stem Cell · 2019
    7. Defining Skin Fibroblastic Cell Types Beyond CD90 Frontiers in Cell and Developmental Biology · 2018
    8. Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations Journal of Investigative Dermatology · 2018
    9. Wound Healing and Skin Regeneration Cold Spring Harbor Perspectives in Medicine · 2015
    10. Macrophages Contribute to the Cyclic Activation of Adult Hair Follicle Stem Cells PLoS Biology · 2014
    11. The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle Cold Spring Harbor Perspectives in Medicine · 2014
    12. Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair Nature · 2013
    13. Autoimmunity: Alopecia Areata Journal of Investigative Dermatology Symposium Proceedings · 2004
    14. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002