Defining Skin Fibroblastic Cell Types Beyond CD90

October 2018 in “ Frontiers in Cell and Developmental Biology ”

Dongsheng Jiang, Yuval Rinkevich

fibroblast CD90 mesenchymal cells lineage tracing fibrosis single-cell transcriptome analysis

TLDR The conclusion is that CD90 is not a specific marker for fibroblast subtypes and better methods are needed to identify them.

The document from October 22, 2018, critiques the use of CD90 as a marker for identifying fibroblast subtypes, pointing out its lack of specificity. It notes that CD90 is found on various mesenchymal cells and does not accurately represent any particular functional fibroblast subtype. The authors recommend that future research should employ lineage tracing to define fibroblast subsets based on their functions rather than CD90 expression. They also highlight the unclear role of CD90 in fibroblasts and its association with fibrosis. The document calls for the discovery of specific markers for fibroblast subsets to improve cell enrichment strategies for clinical use and suggests that single-cell transcriptome analysis might aid in identifying these unique markers.

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Research cited in this study

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research Inhibition of β-Catenin Signaling in Dermal Fibroblasts Enhances Hair Follicle Regeneration During Wound Healing

87 citations, January 2016 in “Development”

Blocking β-catenin in skin cells improves hair growth during wound healing.

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