Defining Skin Fibroblastic Cell Types Beyond CD90

    October 2018 in “ Frontiers in Cell and Developmental Biology ”
    Dongsheng Jiang, Yuval Rinkevich
    Image of study
    TLDR The conclusion is that CD90 is not a specific marker for fibroblast subtypes and better methods are needed to identify them.
    The document from October 22, 2018, critiques the use of CD90 as a marker for identifying fibroblast subtypes, pointing out its lack of specificity. It notes that CD90 is found on various mesenchymal cells and does not accurately represent any particular functional fibroblast subtype. The authors recommend that future research should employ lineage tracing to define fibroblast subsets based on their functions rather than CD90 expression. They also highlight the unclear role of CD90 in fibroblasts and its association with fibrosis. The document calls for the discovery of specific markers for fibroblast subsets to improve cell enrichment strategies for clinical use and suggests that single-cell transcriptome analysis might aid in identifying these unique markers.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 23 results
      [object Object]

      community Breezula phase 3 results said to be released next month

      in Product  25 upvotes 3 weeks ago
      Breezula's phase 3 results are expected soon, with discussions on the effectiveness of androgen receptor antagonists like spironolactone and the potential of GT20029. Users express skepticism about new treatments and discuss the complexities of male pattern baldness, often relying on finasteride despite its side effects.

      community Verteporfin and Microneedling

      in Treatments 7 months ago
      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

    Similar Research

    5 / 1000+ results