Dissecting Fibroblast Heterogeneity in Health and Fibrotic Disease

    June 2020 in “ Current Rheumatology Reports ”
    Tanya J. Shaw, Emanuel Rognoni
    Studysummary This review explores the diverse roles and heterogeneity of fibroblasts across different organs, highlighting their potential involvement in both normal tissue functioning and fibrotic diseases, but reports no new experimental results.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 13

    1. Single-Cell Analysis Reveals Fibroblast Heterogeneity and Myeloid-Derived Adipocyte Progenitors in Murine Skin Wounds Nature Communications · 2019
    2. Hedgehog Stimulates Hair Follicle Neogenesis by Creating Inductive Dermis During Murine Skin Wound Healing Nature Communications · 2018
    3. Lineage Identity and Location Within the Dermis Determine the Function of Papillary and Reticular Fibroblasts in Human Skin Journal of Investigative Dermatology · 2018
    4. Skin Cell Heterogeneity in Development, Wound Healing, and Cancer Trends in cell biology · 2018
    5. SFRP2/DPP4 and FMO1/LSP1 Define Major Fibroblast Populations in Human Skin Journal of Investigative Dermatology · 2018
    6. Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations Journal of Investigative Dermatology · 2018
    7. Fibroblast State Switching Orchestrates Dermal Maturation And Wound Healing bioRxiv (Cold Spring Harbor Laboratory) · 2017
    8. Dermal Fibroblasts in Cutaneous Development and Healing Wiley Interdisciplinary Reviews-Developmental Biology · 2017
    9. Regeneration of Fat Cells from Myofibroblasts During Wound Healing Science · 2017
    10. Inhibition of β-Catenin Signaling in Dermal Fibroblasts Enhances Hair Follicle Regeneration During Wound Healing Development · 2016
    11. Fate of Prominin-1 Expressing Dermal Papilla Cells During Homeostasis, Wound Healing, and Wnt Activation Journal of Investigative Dermatology · 2015
    12. Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair Nature · 2013
    13. Wound Repair at a Glance Journal of Cell Science · 2009