Single-Cell Analysis Reveals Fibroblast Heterogeneity and Myeloid-Derived Adipocyte Progenitors in Murine Skin Wounds

    February 2019 in “ Nature Communications ”
    Christian F. Guerrero-Juarez, Priya H. Dedhia, Suoqin Jin … Maksim V. Plikus
    Studysummary In this study, researchers found that wound healing in mouse skin recruits diverse fibroblasts, including myeloid-derived cells, which contribute to regenerating adipocytes.
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    Research cited in this study 22

    1. Hedgehog Stimulates Hair Follicle Neogenesis by Creating Inductive Dermis During Murine Skin Wound Healing Nature Communications · 2018
    2. Single-Cell Transcriptomics of Traced Epidermal and Hair Follicle Stem Cells Reveals Rapid Adaptations During Wound Healing Cell Reports · 2018
    3. SFRP2/DPP4 and FMO1/LSP1 Define Major Fibroblast Populations in Human Skin Journal of Investigative Dermatology · 2018
    4. Msx2 Supports Epidermal Competency During Wound-Induced Hair Follicle Neogenesis Journal of Investigative Dermatology · 2018
    5. Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations Journal of Investigative Dermatology · 2018
    6. Wound Regeneration Deficit in Rats Correlates with Low Morphogenetic Potential and Distinct Transcriptome Profile of Epidermis Journal of Investigative Dermatology · 2018
    7. Targeting of CXXC5 by a Competing Peptide Stimulates Hair Regrowth and Wound-Induced Hair Neogenesis Journal of Investigative Dermatology · 2017
    8. Epithelial-Mesenchymal Micro-Niches Govern Stem Cell Lineage Choices Cell · 2017
    9. Macrophages Induce AKT/β-Catenin-Dependent Lgr5+ Stem Cell Activation and Hair Follicle Regeneration Through TNF Nature Communications · 2017
    10. Msi2 Maintains Quiescent State of Hair Follicle Stem Cells by Directly Repressing the Hedgehog Signaling Pathway Journal of Investigative Dermatology · 2017
    11. Regeneration of Fat Cells from Myofibroblasts During Wound Healing Science · 2017
    12. Hair Follicles’ Transit-Amplifying Cells Govern Concurrent Dermal Adipocyte Production Through Sonic Hedgehog Genes & Development · 2016
    13. Fate of Prominin-1 Expressing Dermal Papilla Cells During Homeostasis, Wound Healing, and Wnt Activation Journal of Investigative Dermatology · 2015
    14. dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration Cell Stem Cell · 2015
    15. Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair Nature · 2013
    16. Fgf9 From Dermal γδ T Cells Induces Hair Follicle Neogenesis After Wounding Nature Medicine · 2013
    17. Prostaglandin D2 Inhibits Wound-Induced Hair Follicle Neogenesis Through the Receptor Gpr44 Journal of Investigative Dermatology · 2012
    18. Skin Shedding and Tissue Regeneration in African Spiny Mice (Acomys) Nature · 2012
    19. Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration Journal of Investigative Dermatology · 2012
    20. Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling Cell · 2011
    21. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    22. The Formation of Vellus Hair Follicles from Human Adult Epidermis Journal of Investigative Dermatology · 1956

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    1. Rare Gli1+ Perivascular Fibroblasts Promote Skin Wound Repair bioRxiv (Cold Spring Harbor Laboratory) · 2022