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GlossarySingle-cell RNA sequencing (scRNA-seq)

examines gene expression in individual cells for detailed insights

Single-cell RNA sequencing (scRNA-seq) is a powerful technique that allows scientists to examine the gene expression profiles of individual cells. This method provides detailed insights into the cellular diversity within a tissue, revealing how different cells function and interact, which is crucial for understanding complex biological processes and diseases like cancer or alopecia.

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Updated Skin Transcriptomic Atlas Depicted by Reciprocal Contribution of Single-Nucleus RNA Sequencing and Single-Cell RNA Sequencing

research Updated Skin Transcriptomic Atlas Depicted by Reciprocal Contribution of Single-Nucleus RNA Sequencing and Single-Cell RNA Sequencing

April 2023 in “Journal of Investigative Dermatology”

The research updated the skin cell profile, finding new skin cell markers and showing fibroblasts' key role in skin health.

research EMT-Inhibiting Transcription Factor Ovol2 Regulates Directional Cell Migration and Proliferation in Adult Skin Epithelia

April 2018 in “Journal of Investigative Dermatology”

Ovol2 is important for proper skin healing and hair growth.

research Applying FACS-Based Single Cell RNA-Seq to Study Neonatal Mouse Skin

April 2017 in “Journal of Investigative Dermatology”

Researchers improved a method to study individual cells in newborn mouse skin and found a way to assess the severity of a skin condition in humans.

Single Cell Transcriptome Profiling of Human Interfollicular Epidermis Reveals Robust Heterogeneity and Divergent Differentiation Lineages

research Single Cell Transcriptome Profiling of Human Interfollicular Epidermis Reveals Robust Heterogeneity and Divergent Differentiation Lineages

April 2018 in “Journal of Investigative Dermatology”

The human skin's outer layer has more variety in cell types and development paths than previously thought.

research Single-Cell Transcriptomics Reveals the Molecular Anatomy of Sheep Hair Follicle Heterogeneity and Wool Curvature

10 citations , December 2021 in “Frontiers in cell and developmental biology”

The research identified genes that explain why some sheep have curly wool and others have straight wool.

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community End of Hair loss ( AGA ) ? Since they produce it in china probably we don’t need to wait other 10 yrs😁

in Treatment 269 upvotes 1 week ago

GT20029 is a new hair loss treatment in Phase 3 trials in China, using PROTAC technology to target androgen receptors, potentially with fewer side effects than finasteride and minoxidil. VDPHL01, a second-generation minoxidil, is also mentioned as potentially more effective.

community My Theory Of Androgenic Alopecia

in Research/Science 19 upvotes 3 months ago

Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

community Concerns about CosmeRNA safety mechanisms

in Treatment 3 upvotes 2 years ago

Concerns about CosmeRNA safety mechanisms and potential side effects. Discussion includes comparisons to Fluridil and questions about nanoparticle specificity and siRNA stability.

community More great news about SCUBE3... this could be it!

in Research/Science 30 upvotes 3 years ago

SCUBE3 is a potential hair loss treatment that people are hopeful about. It may provide a solution without the side effects of finasteride.

community Anyone excited for CosmeRNA coming this month?

in Product 171 upvotes 3 years ago

CosmeRNA, a new hair loss treatment, is expected to release soon and may become part of the "big three" treatments alongside finasteride and minoxidil. It works differently from finasteride by targeting androgen receptors in hair follicles, potentially offering fewer side effects.

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