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GlossarySingle-cell RNA sequencing (scRNA-seq)

examines gene expression in individual cells for detailed insights

Single-cell RNA sequencing (scRNA-seq) is a powerful technique that allows scientists to examine the gene expression profiles of individual cells. This method provides detailed insights into the cellular diversity within a tissue, revealing how different cells function and interact, which is crucial for understanding complex biological processes and diseases like cancer or alopecia.

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Large-Scale Skin scRNA-Seq Profiling Highlights Distinct Body Site-Specific Ligand-Receptor Interactions and Pathways in Keratinocytes

research Large-Scale Skin scRNA-Seq Profiling Highlights Distinct Body Site-Specific Ligand-Receptor Interactions and Pathways in Keratinocytes

August 2023 in “Journal of Investigative Dermatology”

Different body areas have unique skin cell communication patterns, explaining why certain skin diseases occur in specific regions.

Fibroblast Heterogeneity and Functions: Insights from Single-Cell Sequencing in Wound Healing, Breast Cancer, Ovarian Cancer, and Melanoma

research Fibroblast Heterogeneity and Functions: Insights from Single-Cell Sequencing in Wound Healing, Breast Cancer, Ovarian Cancer, and Melanoma

March 2024 in “Frontiers in genetics”

Different types of fibroblasts play specific roles in wound healing and cancer, which could help improve treatments.

research Molecular Heterogeneity of Quiescent Melanocyte Stem Cells Revealed by Single-Cell RNA-Sequencing

December 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

Different types of inactive melanocyte stem cells exist with unique characteristics and potential to develop into other cells.

research Mapping Human Skin: One Sequenced Cell at a Time

November 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

The article concludes that creating a detailed map of normal human skin at the single-cell level is important.

Updated Skin Transcriptomic Atlas Depicted by Reciprocal Contribution of Single-Nucleus RNA Sequencing and Single-Cell RNA Sequencing

research Updated Skin Transcriptomic Atlas Depicted by Reciprocal Contribution of Single-Nucleus RNA Sequencing and Single-Cell RNA Sequencing

April 2023 in “Journal of Investigative Dermatology”

The research updated the skin cell profile, finding new skin cell markers and showing fibroblasts' key role in skin health.

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community Concerns about CosmeRNA safety mechanisms

in Treatment 3 upvotes 1 year ago

Concerns about CosmeRNA safety mechanisms and potential side effects. Discussion includes comparisons to Fluridil and questions about nanoparticle specificity and siRNA stability.

community Since there is so much hype for cosmeRNA and HMI-115...

in Chat 48 upvotes 1 year ago

Exploring different treatments for hair loss, such as cosmeRNA and HMI-115 which are small interference messenger RNA that inhibits the DHT receptor and an antibody that binds to the prolactin (PRL) receptor respectively; and researching mechanism and environment of hyperresponders.

community Sandalore: a scientific homemade approch

20 upvotes 6 years ago

The post discusses using Sandalore as a potential hair loss treatment, emphasizing precise measurements and safe handling. The user compares Sandalore's effects to Minoxidil and mentions preparing a solution with ethanol and DMSO.

community cosmeRNA finally now it's pyrilutamide turn

in Chat 49 upvotes 1 year ago

Hair loss treatments discussed include cosmeRNA, minoxidil, finasteride, RU58841, and pyrilutamide. Users debate effectiveness, side effects, and upcoming treatments, with some expressing skepticism and others optimism.

community Anyone excited for CosmeRNA coming this month?

in Product 171 upvotes 1 year ago

CosmeRNA, a new hair loss treatment, is expected to release soon and may become part of the "big three" treatments alongside finasteride and minoxidil. It works differently from finasteride by targeting androgen receptors in hair follicles, potentially offering fewer side effects.

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