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Glossary Small Interfering RNA

molecule that silences specific genes by degrading their mRNA

Small Interfering RNA (siRNA) is a type of molecule that can silence or "turn off" specific genes within a cell. It works by binding to a complementary messenger RNA (mRNA) sequence, leading to its degradation and preventing the production of the corresponding protein. This mechanism is often used in research and therapeutic applications to study gene function or to target and reduce the expression of disease-related genes.

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Research

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research Controlled Delivery of T-box21 Small Interfering RNA Ameliorates Autoimmune Alopecia (Alopecia Areata) in a C3H/HeJ Mouse Model

69 citations , February 2008 in “The American journal of pathology”

This study found that local injections of interleukin-4 and neutralizing anti-interferon-γ antibody effectively treated alopecia in a mouse model, suggesting potential therapeutic pathways for human alopecia areata.

The Circular RNA CircCOL1A1 Functions as a miR-149-5p Sponge to Regulate the Formation of Superior-Quality Brush Hair via the CMTM3/AR Axis

research The Circular RNA CircCOL1A1 Functions as a miR-149-5p Sponge to Regulate the Formation of Superior-Quality Brush Hair via the CMTM3/AR Axis

3 citations , February 2022 in “Frontiers in cell and developmental biology”

This study found that the circular RNA circCOL1A1 influences the formation of superior-quality brush hair in white goats by regulating hair follicle stem cell behavior and interacting with the miR-149-5p/CMTM3/AR axis.

research Identification and Characterization of a Novel Lysophosphatidic Acid Receptor, p2y5/LPA6

253 citations , April 2009 in “Journal of Biological Chemistry”

This study found that p2y5 functions as a novel LPA receptor involved in the G13-Rho signaling pathway, with implications for human hair growth, and proposes renaming it to LPA6.

research Keratin disorders: from gene to therapy

109 citations , September 2011 in “Human molecular genetics online/Human molecular genetics”

This review discusses keratin disorders and potential RNA interference therapeutics, reporting no new clinical findings but highlighting the promise of siRNA for future treatments.

research Advances in transdermal siRNAs delivery: A review of current research progress

20 citations , May 2023 in “Non-coding RNA Research”

This review discusses recent advancements in developing delivery systems for small interfering RNA (siRNA) to treat skin conditions, highlighting innovations like liposomes, dendrimers, cell-penetrating peptides, and spherical nucleic acid nanoparticles designed to overcome challenges of skin permeability and degradation.

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Community Join

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community How is this even possible that there is no cure till now

in Technology 155 upvotes 4 months ago

There is no permanent cure for hair loss; treatments like finasteride, minoxidil, and hair transplants require ongoing use and are not universally effective. Genetic complexity and financial incentives for ongoing treatments hinder the development of a definitive cure.

community After praising finasteride on this sub for a while I realised it gave me Brain Fog. I think its related to inhibiting GABA and interferring with mirtazapine (an antidepressant).

9 upvotes 6 years ago

Finasteride caused brain fog and reduced the effectiveness of mirtazapine for the user, leading them to stop finasteride and notice improvements in motivation and focus. The user suggests that finasteride might be incompatible with mirtazapine for some people and recommends mirtazapine for those experiencing mental fog from finasteride.

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Learn

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learn Stem Cell Factor

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