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    Glossary PP405

    novel molecule for treating hair loss by targeting MPC

    PP405 is a novel small molecule developed by Pelage Pharmaceuticals for the treatment of hair loss, specifically targeting mitochondrial pyruvate carrier (MPC).

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    1. PP405 mitochondrial pyruvate carrier (MPC) inhibitor by Pelage in early trials

    Research 4 of 31

    1. PP405 in Alopecia: An Emerging Molecule worth Investigating Journal of Community Medicine and Health Solutions · 2026
    2. Diagnostic Comparison: SH‑1 Molecule vs PP405 — Safety Profiles in Hair Science HAL (Le Centre pour la Communication Scientifique Directe) · 2026
    3. LB1045 Inhibition of pyruvate oxidation activates human hair follicle stem cells ex vivo Journal of Investigative Dermatology · 2024
    4. Review of the 2024 American Academy of Dermatology (AAD) Annual Meeting 2024
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    Community 10 of 315

    1. Phase 3 Study for PP405 officially posted Reddit · 16 Sept 2026
    2. Pelage Pharmaceuticals Phase 3 Trials for PP405 Start in September 2026 Reddit · 15 Sept 2026
    3. Pelage have made a new post about PP405 Reddit · 19 Aug 2026
    4. Pelage will be presenting PP405 at the Masters of Aesthetics which is held from 28-30th August Reddit · 16 Aug 2026
    5. Phase 3 for PP405 will now start in 2027 Reddit · 14 Aug 2026
    6. Why is everyone still arguing about PP405 when clascoterone is already heading toward regulatory submission? Reddit · 13 Aug 2026
    7. Did some new info come out about PP405? Everyone seems so pessimistic about it recently and I don’t know why. Reddit · 11 Aug 2026
    8. Why PP405 may not be dead just yet Reddit · 9 Aug 2026
    9. PP405 (JXL069) Is Confirmed: Here’s Everything I’ve Learned After a Year of Testing Reddit · 30 Jul 2026
    10. Why you can still look forward to PP405 and JXL-069 Reddit · 29 Jul 2026
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