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GlossaryRNA-induced silencing complex

The RNA-induced silencing complex (RISC) is a molecular machine within cells that plays a crucial role in gene regulation. It uses small RNA molecules, such as microRNAs (miRNAs) or small interfering RNAs (siRNAs), to identify and bind to specific messenger RNA (mRNA) sequences, leading to the degradation of the mRNA or the inhibition of its translation into proteins. This process is essential for controlling gene expression and maintaining cellular function.

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research Control by a Hair’s Breadth: The Role of MicroRNAs in the Skin

41 citations, September 2012 in “Cellular and Molecular Life Sciences”

MicroRNAs play a crucial role in skin and hair health, affecting everything from growth to aging, and could potentially be used in treating skin diseases.

research A Perspective on RNAi-Based Biopesticides

140 citations, February 2020 in “Frontiers in Plant Science”

RNAi-based biopesticides could be safe and effective for pest control with careful development and risk assessment.

research Promoting Axonal Regeneration Through Exosomes: An Update of Recent Findings on Exosomal PTEN and mTOR Modifiers

14 citations, October 2018 in “Brain Research Bulletin”

Exosomes help nerve fibers grow by affecting specific cell signaling pathways.

research Deciphering the Mesodermal Potency of Porcine Skin-Derived Progenitors by Microarray Analysis

6 citations, April 2010 in “Cellular Reprogramming”

Pig skin cells can turn into mesodermal cells but lose their ability to become neural cells.

research The Roles of Non-Coding RNA in the Development and Regeneration of Hair Follicles: Current Status and Further Perspectives

11 citations, October 2021 in “Frontiers in Cell and Developmental Biology”

Non-coding RNAs are important for hair growth and could lead to new hair loss treatments, but more research is needed.

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community My Testosterone results before and after Finasteride

in Update 150 upvotes 3 years ago

Finasteride significantly increased testosterone levels for the user, with no major side effects except watery semen, which was resolved with zinc supplements. The user's hairline stopped receding and slightly improved.

community Quit vaping/smoking = 80% less loss

in Research/Science 214 upvotes 5 months ago

Quitting vaping significantly reduced hair loss for a user who was a heavy vaper and also taking finasteride. Some participants suggest nicotine's vasoconstrictive properties may worsen hair loss, while others share personal anecdotes of hair improvement after quitting smoking or vaping.

community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 445 upvotes 3 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.

community When someone posts a scalp tension theory

in Satire 268 upvotes 3 years ago

Hair loss theories discussed include poor blood flow, scalp tension, inflammation, and DHT. Treatments mentioned are massaging scalp, minoxidil, finasteride, and RU58841.

community Since there is so much hype for cosmeRNA and HMI-115…

in Chat 47 upvotes 1 year ago

Exploring different treatments for hair loss, such as cosmeRNA and HMI-115 which are small interference messenger RNA that inhibits the DHT receptor and an antibody that binds to the prolactin (PRL) receptor respectively; and researching mechanism and environment of hyperresponders.

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