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GlossaryRNA-induced silencing complex

molecular machine that regulates gene expression by degrading mRNA

The RNA-induced silencing complex (RISC) is a molecular machine within cells that plays a crucial role in gene regulation. It uses small RNA molecules, such as microRNAs (miRNAs) or small interfering RNAs (siRNAs), to identify and bind to specific messenger RNA (mRNA) sequences, leading to the degradation of the mRNA or the inhibition of its translation into proteins. This process is essential for controlling gene expression and maintaining cellular function.

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research Gene Therapy to Enhance Angiogenesis in Chronic Wounds

36 citations , August 2022 in “Molecular Therapy — Nucleic Acids”

Gene therapy shows promise for healing chronic wounds but needs more research to overcome challenges.

research The Roles of Non-Coding RNA in the Development and Regeneration of Hair Follicles: Current Status and Further Perspectives

11 citations , October 2021 in “Frontiers in Cell and Developmental Biology”

Non-coding RNAs are important for hair growth and could lead to new hair loss treatments, but more research is needed.

research Retracted Article: Up-Regulated lncRNA5322 Elevates MAPK1 to Enhance Proliferation of Hair Follicle Stem Cells as a ceRNA of microRNA-19b-3p

9 citations , June 2019 in “Cell cycle/Cell cycle (Georgetown, Tex. Online)”

A specific RNA increases hair stem cell growth and skin healing by affecting a protein through interaction with a microRNA.

research An Investigation of Keratin 15 Function by Small Interfering RNA Technology

January 2012 in “Durham e-Theses (Durham University)”

Keratin 15 affects cell behavior and characteristics in skin cells.

research EMT Factors and Metabolic Pathways in Cancer

346 citations , April 2020 in “Frontiers in Oncology”

EMT and metabolic pathways help cancer cells resist treatment and spread.

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community My Testosterone results before and after Finasteride

in Update 151 upvotes 4 years ago

Finasteride significantly increased testosterone levels for the user, with no major side effects except watery semen, which was resolved with zinc supplements. The user's hairline stopped receding and slightly improved.

community We need to keep these snake oil companies accountable.

in Treatment 120 upvotes 1 year ago

Biotin is being misleadingly marketed as a primary treatment for androgenic alopecia, overshadowing more effective treatments like finasteride and minoxidil. There is a call for increased awareness and accountability to prevent misinformation.

community Baldness Breakthrough: microRNA Stimulates Hair Growth in Aging Follicles

in Technology 320 upvotes 2 years ago

miR-205, a tiny RNA, can stimulate hair growth by softening aging hair follicle stem cells in mice. Future tests aim to see if this can work in humans.

community Has anyone tried Exosomes from Musely or somewhere else?

in Hair Systems 10 upvotes 11 months ago

Exosomes from Musely are being discussed as a topical hair loss treatment containing ingredients like latanoprost, caffeine, cetirizine, melatonin, vitamin D3, vitamin E, and biotin. Users are curious about its effectiveness and potential side effects, noting it may take 4-6 months to see results.

community My Theory Of Androgenic Alopecia

in Research/Science 19 upvotes 4 months ago

Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

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