A Perspective on RNAi-Based Biopesticides

The 2020 review article discussed the potential of RNA interference (RNAi)-based biopesticides as a sustainable solution for controlling plant pests and pathogens. It highlighted the benefits of using double-stranded RNA (dsRNA) for species-specific pest control without genetically modifying crops and the minimal environmental impact with proper dsRNA design. However, challenges such as stable dsRNA delivery, extending protection duration, and potential unintended human health and environmental impacts were noted. The review suggested that human health risks are minimal due to barriers to dsRNA uptake and that environmental risks can be mitigated with bioinformatics-based dsRNA design. The document cited the susceptibility of the Colorado potato beetle to dsRNA and the use of nanocarriers like clay nanoparticles for improved delivery. It also referenced Australia's regulatory stance, where RNAi techniques that apply RNA to plants are not regulated under certain conditions. The paper concluded that with careful development and risk assessment, RNAi-based biopesticides could be a safe and effective pest control tool.