Noncoding dsRNA Induces Retinoic Acid Synthesis to Stimulate Hair Follicle Regeneration via TLR3

    June 2019 in “ Nature Communications
    Dong-Won Kim, Ruosi Chen, Mary Sheu, Noori Kim, Soo Rin Kim, Nasif Islam, Eric M. Wier, Gaofeng Wang, Ang Li, Angela Park, Wooyang Son, Benjamin A. Evans, Victoria Y. Yu, Vicky P. Prizmic, Eugene Oh, Zixiao Wang, Jianshi Yu, Weiliang Huang, Nathan K. Archer, Zhiqi Hu, Nashay N. Clemetson, Amanda E. Nelson, Anna L. Chien, Ginette A. Okoye, Lloyd S. Miller, Gabriel Ghiaur, Sewon Kang, Jace W. Jones, Maureen A. Kane, Luis A. Garza
    Image of study
    TLDR Noncoding dsRNA boosts hair growth by activating TLR3 and increasing retinoic acid.
    The study found that noncoding dsRNA activates TLR3 to induce intrinsic retinoic acid (RA) synthesis, which promotes hair follicle regeneration. The study used mouse models and human samples to demonstrate that TLR3 agonists combined with RA might enhance regeneration in humans. The study provides new insights into the mechanisms of hair follicle regeneration and could lead to the development of new therapies for hair loss.
    Discuss this study in the Community →

    Research cited in this study

    11 / 11 results

    Related Community Posts Join

    0 / 0 results
    — no results

    Related Research

    4 / 4 results