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GlossaryToll-like receptor 3 (TLR3)

detects viral RNA to trigger immune responses

Toll-like receptor 3 (TLR3) is a protein that plays a crucial role in the immune system by recognizing and responding to viral infections. It detects double-stranded RNA, a molecular pattern associated with many viruses, and triggers an immune response to help fight off the infection.

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research Neutrophil Extracellular Traps Impair Regeneration

4 citations, October 2021 in “Journal of Cellular and Molecular Medicine”

White blood cells and their traps can slow down the process of new hair growth after a wound.

research Noncoding dsRNA Induces Retinoic Acid Synthesis to Stimulate Hair Follicle Regeneration via TLR3

47 citations, June 2019 in “Nature Communications”

Noncoding dsRNA boosts hair growth by activating TLR3 and increasing retinoic acid.

research dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration

128 citations, August 2015 in “Cell Stem Cell”

Damage to skin releases dsRNA, which activates TLR3 and helps in skin and hair follicle regeneration.

research Non-Coding Double-Stranded RNA Induces Retinoic Acid Synthesis and Retinoid Signaling to Control Regeneration

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

Double-stranded RNA helps regenerate hair follicles by increasing retinoic acid production and signaling.

research Hypothesis: Wound-Induced TLR3 Activation Stimulates Endogenous Retinoic Acid Synthesis and Signalling During Regeneration

5 citations, March 2019 in “Experimental dermatology”

Activating TLR3 may help produce retinoic acid, important for tissue regeneration.

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