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GlossaryToll-like receptor 3 (TLR3)

detects viral RNA to trigger immune responses

Toll-like receptor 3 (TLR3) is a protein that plays a crucial role in the immune system by recognizing and responding to viral infections. It detects double-stranded RNA, a molecular pattern associated with many viruses, and triggers an immune response to help fight off the infection.

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research dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration

128 citations , August 2015 in “Cell Stem Cell”

Damage to skin releases dsRNA, which activates TLR3 and helps in skin and hair follicle regeneration.

research The L412F Variant of Toll-Like Receptor 3 Is Associated with Cutaneous Candidiasis, Increased Susceptibility to Cytomegalovirus, and Autoimmunity

55 citations , November 2010 in “Journal of Allergy and Clinical Immunology”

The L412F variant of TLR3 is linked to skin infections, more viral infections, and autoimmune issues.

research Noncoding dsRNA Induces Retinoic Acid Synthesis to Stimulate Hair Follicle Regeneration via TLR3

47 citations , June 2019 in “Nature Communications”

Noncoding dsRNA boosts hair growth by activating TLR3 and increasing retinoic acid.

research Activation of TLR3 Enhances Stemness and Immunomodulatory Properties of Periodontal Ligament Stem Cells

3 citations , December 2016 in “Springer eBooks”

Activating TLR3 improves the healing and immune properties of periodontal ligament stem cells.

research TLR3 Signaling Modulates Immunomodulatory Property of Human Periodontal Ligament Stem Cells

January 2018

TLR3 signaling enhances the immunosuppressive properties of human periodontal ligament stem cells.

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