Activation of TLR3 Enhances Stemness and Immunomodulatory Properties of Periodontal Ligament Stem Cells

The study conducted on December 10, 2016, explored the impact of Toll-like receptor 3 (TLR3) on periodontal ligament stem cells (PDLSCs). The researchers discovered that TLR3 stimulation significantly increased the expression of pluripotent stem cell genes (REX-1 and SOX2) and immunomodulatory molecules (IFNγ and IDO). The inhibition of NF-kB signaling influenced the TLR3-activated IFNγ and IDO expression, suggesting multiple pathways in the inductive mechanism. The study concluded that TLR3 activation could enhance the stem cell and immunosuppressive properties of PDLSCs, potentially aiding tissue healing and regeneration. Therefore, TLR3 activation in PDL cells could lead to effective periodontal ligament tissue regeneration.