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Glossary Toll-like receptor 3

detects viral RNA to trigger immune responses

Toll-like receptor 3 (TLR3) is a protein that plays a crucial role in the immune system by recognizing and responding to viral infections. It detects double-stranded RNA, a molecular pattern associated with many viruses, and triggers an immune response to help fight off the infection.

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Research

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research The L412F variant of Toll-like receptor 3 (TLR3) is associated with cutaneous candidiasis, increased susceptibility to cytomegalovirus, and autoimmunity

55 citations , November 2010 in “Journal of Allergy and Clinical Immunology”

This study found that the TLR3 L412F genetic variant is associated with severe viral infections, especially CMV, and immune dysfunction in a subgroup of chronic mucocutaneous candidiasis patients.

research Toll-like Receptor 3 Agonist, Polyinosinic-polycytidylic Acid, Upregulates Carbonic Anhydrase II in Human Keratinocytes

9 citations , January 2018 in “Acta dermato-venereologica”

This study found that carbonic anhydrase II was significantly upregulated in human keratinocytes when treated with toll-like receptor 3 agonist and Th2 cytokines, suggesting its potential role in inflammatory skin conditions.

A Population of Radio-Resistant Macrophages in the Deep Myenteric Plexus Contributes to Postoperative Ileus Via Toll-Like Receptor 3 Signaling

research A Population of Radio-Resistant Macrophages in the Deep Myenteric Plexus Contributes to Postoperative Ileus Via Toll-Like Receptor 3 Signaling

6 citations , January 2021 in “Frontiers in Immunology”

This study found that deficiency in TLR3/TRIF signaling reduced inflammation and protected mice against postoperative ileus, suggesting potential for TLR3 antagonism as a preventive approach in humans.

research The pattern recognition receptor toll-like receptor 3 regulates skin barrier homeostasis

January 2014 in “eScholarship (California Digital Library)”

In this study, researchers observed that TLR3 and scavenger receptors play key roles in skin barrier repair following UVB damage, contributing to our understanding of cellular responses to skin injury.

research Toll-Like Receptor Function in Acute Wounds

65 citations , May 2017 in “Advances in wound care”

This review discusses the role of Toll-like receptors in wound healing and highlights their potential therapeutic value but notes that their role in human wound healing and chronic wounds is not well understood.

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Community Join

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community Why does MPB only affect the scalp

in Research/Science 14 upvotes 1 year ago

Male pattern baldness (MPB) may be influenced by androgen receptors in scalp hair follicles and potentially poor blood flow. Transplanted hair is not immune to DHT, and factors like inflammation and scalp tension might also contribute to hair loss.

community Popular hair loss drug linked to higher suicide risk: compared to non-users, finasteride (Proscar/ Propecia) users have a markedly increased risk of depression, anxiety, and suicidal thoughts. Over 30 years of observation, 19,320 suicides were expected.

494 upvotes 11 months ago

Finasteride users may have an increased risk of depression, anxiety, and suicidal thoughts, though some attribute these issues to hair loss itself. The link between finasteride and mental health effects is debated, with varying user experiences.

community I’m considering stopping finasteride

in Finasteride/Dutasteride 157 upvotes 8 months ago

The user is considering stopping finasteride due to depression, anxiety, and difficulty building muscle, despite its effectiveness in stopping hair loss. Suggestions include reducing the dose, switching to topical solutions, or consulting a doctor for alternatives like dutasteride or RU58841.

community Oral Minoxidil Secret Very important

in Minoxidil 237 upvotes 1 year ago

Oral minoxidil can cause side effects like shortness of breath and constipation, which may be reduced by taking it in the morning. Some users experience no side effects, while others switch to topical treatments or adjust their dosage and timing to manage symptoms.

community 6 months of treatment, best decision of my life.

in Progress Pictures 5817 upvotes 1 year ago

Significant hair regrowth and increased confidence after using 1 mg finasteride for 6 months and 5 mg oral minoxidil for 3 months. No major side effects, except unwanted hair growth near temples and eyebrows.

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Learn

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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Hair Systems
Tolle & LockeWaltershausen, Thüringen · DE

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