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Glossary Pathogen-associated molecular patterns

molecules on pathogens recognized by the immune system

Pathogen-associated molecular patterns (PAMPs) are molecules found on the surface of pathogens like bacteria, viruses, and fungi that are recognized by the immune system. These patterns are essential for the immune system to identify and respond to infections, as they trigger an immune response by binding to specific receptors on immune cells, such as Toll-like receptors (TLRs).

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research A molecular wound response program associated with regeneration initiation in planarians

212 citations , May 2012 in “Genes & Development”

This study identified a set of wound-induced genes in planarians that play a role in regeneration initiation, with some genes specifically activating within regenerative cells called neoblasts.

research Skin inflammation activates intestinal stromal fibroblasts and promotes colitis

37 citations , October 2021 in “Journal of Clinical Investigation”

This study suggests that inflammation in the skin can exacerbate intestinal inflammation in inflammatory bowel diseases by activating fibroblasts in the colon through hyaluronan fragments released during skin inflammation.

research Decay of Skin-Specific Gene Modules in Pangolins

1 citations , May 2023 in “Journal of molecular evolution”

This study explored the molecular biology of skin adaptations in pangolins, revealing that certain genes for lipid synthesis have inactive patterns, while others related to skin function remain intact, suggesting complex evolutionary changes in their skin physiology.

research Aging Skin: A Window to the Body

1 citations , April 2016 in “CRC Press eBooks”

Skin aging reflects overall body aging and can indicate internal health conditions.

research Convergent Decay of Skin-specific Gene Modules in Pangolins

1 citations , December 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study investigated pangolin skin genetics, finding that while sweat gland-related genes are not inactivated, several genes related to sebaceous gland function are, which highlights complex evolutionary adaptations in mammalian skin.

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