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GlossaryM2 Macrophages

immune cells aiding tissue repair and reducing inflammation

M2 macrophages, also known as alternatively activated macrophages, are a type of immune cell that plays a crucial role in tissue repair, wound healing, and anti-inflammatory responses. Unlike M1 macrophages, which are involved in pro-inflammatory and pathogen-killing activities, M2 macrophages help to resolve inflammation and promote tissue regeneration.

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research Dual-Action Icariin-Containing Thermosensitive Hydrogel for Wound Macrophage Polarization and Hair Follicle Neogenesis

6 citations, June 2022 in “Frontiers in Bioengineering and Biotechnology”

The gel with icariin speeds up wound healing, reduces scarring, and helps hair growth by controlling BMP4 signaling. It also reduces inflammation and improves wound quality in mice, adapts to different wound shapes, and gradually releases icariin to aid healing. It also prevents too much collagen and myofibroblast formation during skin healing.

research Macrophages Are Necessary for Skin Regeneration During Tissue Expansion

44 citations, January 2019 in “Journal of Translational Medicine”

Macrophages are essential for successful skin growth in reconstructive surgery.

research 5-Bromo-2′-Deoxyuridine Induced Effluvium via p53-Mediated CD326-Positive Keratinocyte Apoptosis in C57BL/6 Mice

August 2016 in “Journal of Dermatology”

A chemical called 5-Bromo-2′-deoxyuridine caused rapid hair loss in mice by killing certain skin cells through a specific cell death pathway.

Sustained Exosome-Guided Macrophage Polarization Using Hydrolytically Degradable PEG Hydrogels for Cutaneous Wound Healing: Identification of Key Proteins and miRNAs, and Sustained Release Formulation

research Sustained Exosome-Guided Macrophage Polarization Using Hydrolytically Degradable PEG Hydrogels for Cutaneous Wound Healing: Identification of Key Proteins and miRNAs, and Sustained Release Formulation

40 citations, March 2022 in “Small”

Hydrogel with M2-derived exosomes improves wound healing by slowly releasing exosomes that help reduce inflammation and promote tissue repair.

research A Case of Sarcoidal Foreign Body Reaction to Permanent Makeup: The Involvement of M2 Macrophages

October 2024 in “Journal of Cutaneous Immunology and Allergy”

Steroid injections improved symptoms and hair regrowth in a woman with a reaction to permanent makeup.

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community 5 months progress post on topical min and fin

in Is this regrowth? 27 upvotes 7 months ago

User shared a 5-month progress update on using topical minoxidil 6% and finasteride 0.05% once daily, with microneedling and vitamins. They experienced initial shedding but no side effects, and increased the treatment to twice daily after month 4.

community Why Diffuse Thinning is Worse Than a Receding Hairline

in Research/Science 149 upvotes 4 months ago

Diffuse thinning is worse than a receding hairline as it affects the entire scalp, complicating styling and hair transplants. Treatments like finasteride, minoxidil, dutasteride, and RU58841 are mentioned, with some users noting improved hair density.

community The Cure isn't 5 years away; it's already here.

in Research/Science 1006 upvotes 2 months ago

PP405 is a new topical treatment for hair loss, showing promise in trials but still requires finasteride for maintenance. There is skepticism about its effectiveness and safety, with concerns about needing finasteride to maintain results.

community How to prevent hair loss while taking creatine?

in Research/Science 4 upvotes 7 months ago

A user is concerned about hair loss from creatine and asks for precautions, mentioning treatments like Minoxidil, finasteride, and ketoconazole shampoo. Replies vary, with some users sharing personal experiences and others dismissing the concern.

community Just to show you the superiority of dutasteride over finasteride (it's huge)

in Research/Science 58 upvotes 8 months ago

Dutasteride is shown to be significantly more effective than finasteride for treating male androgenic alopecia. Users discuss the difficulty of obtaining dutasteride in some countries and share personal experiences with its effectiveness and side effects.

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