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Glossary Macrophage Polarization

process where immune cells change roles based on signals

Macrophage polarization refers to the process by which macrophages, a type of immune cell, change their functional state in response to different signals in their environment. They can adopt a pro-inflammatory state (M1) to fight infections or a healing state (M2) to repair tissues. This ability to switch roles is crucial for maintaining balance in the immune system and is important in conditions like infections, cancer, and autoimmune diseases.

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research Bioactive antiinflammatory antibacterial hemostatic citrate-based dressing with macrophage polarization regulation for accelerating wound healing and hair follicle neogenesis

61 citations , September 2020 in “Bioactive Materials”

This study found that the multifunctional FEA-PCEI dressing significantly accelerated wound healing, reduced scar formation, and promoted hair follicle neogenesis while providing antibacterial and anti-inflammatory benefits.

research Intrinsic ROS Drive Hair Follicle Cycle Progression by Modulating DNA Damage and Repair and Subsequently Hair Follicle Apoptosis and Macrophage Polarization

20 citations , January 2022 in “Oxidative Medicine and Cellular Longevity”

This study found that intrinsic reactive oxygen species drive the hair follicle cycle progression through DNA damage and repair, apoptosis, and macrophage polarization, influencing hair loss and regeneration dynamics in mice.

research Macrophage Polarization: A Novel Target and Strategy for Pathological Scarring

4 citations , October 2024 in “Tissue Engineering and Regenerative Medicine”

research CuATSM Enhances Wound Repair Without Scarring via Hippo/YAP Signalling Pathway to Reduce Ferroptosis and Macrophage Polarisation

3 citations , June 2025 in “Journal of Cellular and Molecular Medicine”

This study using a mouse model reports that CuATSM treatment accelerates skin wound healing and reduces scar formation, with effects possibly mediated via the ferroptosis-induced Hippo/YAP signaling pathway and macrophage polarization, suggesting CuATSM as a potential therapy for scarless wound healing in clinical settings.

research Human adipose tissue-derived small extracellular vesicles promote soft tissue repair through modulating M1-to-M2 polarization of macrophages

2 citations , April 2023 in “Stem Cell Research & Therapy”

This study found that small extracellular vesicles derived from human adipose tissue could promote soft tissue regeneration and increase M2 macrophage polarization, suggesting a promising cell-free approach to tissue repair.

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