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GlossaryM1 Macrophages

pro-inflammatory immune cells activated to fight infections

M1 macrophages, also known as classically activated macrophages, are a type of immune cell that plays a crucial role in the body's defense against infections. They are activated in response to signals like interferon-gamma (IFN-γ) and are known for their pro-inflammatory properties, which help to kill pathogens and initiate inflammation. These cells are essential for fighting off infections but can also contribute to chronic inflammation if not properly regulated.

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Sustained Exosome-Guided Macrophage Polarization Using Hydrolytically Degradable PEG Hydrogels for Cutaneous Wound Healing: Identification of Key Proteins and miRNAs, and Sustained Release Formulation

research Sustained Exosome-Guided Macrophage Polarization Using Hydrolytically Degradable PEG Hydrogels for Cutaneous Wound Healing: Identification of Key Proteins and miRNAs, and Sustained Release Formulation

40 citations , March 2022 in “Small”

Hydrogel with M2-derived exosomes improves wound healing by slowly releasing exosomes that help reduce inflammation and promote tissue repair.

All-In-One Polysaccharide Hydrogel With Resistant Vascular Burst Pressure And Cooperative Wound Microenvironment Regulation For Fatal Arterial Hemorrhage And Diabetic Wound Healing

research All-In-One Polysaccharide Hydrogel With Resistant Vascular Burst Pressure And Cooperative Wound Microenvironment Regulation For Fatal Arterial Hemorrhage And Diabetic Wound Healing

June 2024 in “International journal of biological macromolecules”

The hydrogel effectively stops bleeding and heals diabetic wounds quickly.

research Macrophage Related Chronic Inflammation in Non-Healing Wounds

228 citations , June 2021 in “Frontiers in Immunology”

Macrophage issues cause chronic wound inflammation, but therapies can help.

research Intrinsic ROS Drive Hair Follicle Cycle Progression by Modulating DNA Damage and Repair and Subsequently Hair Follicle Apoptosis and Macrophage Polarization

20 citations , January 2022 in “Oxidative Medicine and Cellular Longevity”

Reactive oxygen species (ROS) influence hair growth by causing DNA damage, cell death, and changes in immune cells.

research The Role of Schwann Cell-Macrophage Interactions in Keloid Pathogenesis

July 2025 in “Journal of Investigative Dermatology”

Schwann cell and M2 macrophage interactions contribute to keloid growth by increasing matrix deposition.

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community Just to show you the superiority of dutasteride over finasteride (it's huge)

in Research/Science 58 upvotes 1 year ago

Dutasteride is shown to be significantly more effective than finasteride for treating male androgenic alopecia. Users discuss the difficulty of obtaining dutasteride in some countries and share personal experiences with its effectiveness and side effects.

community Hair loss over a year following depression and taking antidepressants

in Side effects? 201 upvotes 2 months ago

A 33-year-old experienced significant hair loss after a depressive episode and taking paroxetine, possibly due to telogen effluvium or androgenic alopecia. Suggestions included reducing alcohol, considering finasteride and minoxidil, and consulting a doctor about antidepressant side effects.

community 32 M 1 year anniversary on Fin

in Progress Pictures 154 upvotes 1 year ago

A 32-year-old man has been using topical minoxidil for 11 years and oral finasteride for 1 year, along with a dermaroller, and is happy with his hair regrowth progress without experiencing side effects. Commenters are impressed and some are considering starting finasteride after seeing his results.

community [25 M] 1-year progress, really happy so far

in Progress Pictures 66 upvotes 1 year ago

A user shared their 1-year hair regrowth progress using 1mg oral Finasteride, 5mg oral Minoxidil, 6% Minoxidil spray, Ketoconazole shampoo, and Hawthorne thickening shampoo and conditioner. They experienced thicker body hair as a side effect but no other issues.

community (22 M) 1 month on Minoxidil + Topical Fin + Dermarolling – Am I on the right track? Need advice

in Progress Pictures 6 upvotes 3 months ago

A 22-year-old is using Minoxidil, topical Finasteride, and dermarolling for hair loss, seeing tiny colorless hairs after one month. Users advise patience, suggesting visible results may take 3-6 months, with significant progress over years, and recommend considering oral treatments and possibly a hair transplant in the future.

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