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    Glossary M1 Macrophages

    pro-inflammatory immune cells activated to fight infections

    M1 macrophages, also known as classically activated macrophages, are a type of immune cell that plays a crucial role in the body's defense against infections. They are activated in response to signals like interferon-gamma (IFN-γ) and are known for their pro-inflammatory properties, which help to kill pathogens and initiate inflammation. These cells are essential for fighting off infections but can also contribute to chronic inflammation if not properly regulated.

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    1. Single-Cell RNA Sequencing Reveals Cellular and Transcriptional Changes Associated With M1 Macrophage Polarization in Hidradenitis Suppurativa Frontiers in medicine · 2021 · 22 citations
    2. Cedrol from Platycladus orientalis (L.) Franco regulates M1/M2 polarization of macrophages and promotes hair regeneration Journal of Ethnopharmacology · 2026
    3. ANALYSIS OF THE BACKGROUND LEVEL OF CYTOKINES M1 AND M2 OF THE MACROPHAGE PHENOTYPE IN PATIENTS WITH REVISION RHINOPLASTY AFTER THE USE OF THE DRUG PDRN Fìzìologìčnij žurnal · 2025
    4. Human adipose tissue-derived small extracellular vesicles promote soft tissue repair through modulating M1-to-M2 polarization of macrophages Stem Cell Research & Therapy · 2023 · 2 citations
    5. Macrophage Related Chronic Inflammation in Non-Healing Wounds Frontiers in Immunology · 2021 · 228 citations
    6. Macrophages are necessary for skin regeneration during tissue expansion Journal of Translational Medicine · 2019 · 44 citations
    7. Sustained Exosome‐Guided Macrophage Polarization Using Hydrolytically Degradable PEG Hydrogels for Cutaneous Wound Healing: Identification of Key Proteins and MiRNAs, and Sustained Release Formulation Small · 2022 · 40 citations
    8. Intrinsic ROS Drive Hair Follicle Cycle Progression by Modulating DNA Damage and Repair and Subsequently Hair Follicle Apoptosis and Macrophage Polarization Oxidative Medicine and Cellular Longevity · 2022 · 20 citations
    9. 0867 The role of schwann cell - macrophage interactions in keloid pathogenesis Journal of Investigative Dermatology · 2025
    10. Recombinant Human Annexin A5 Ameliorates Localized Scleroderma by Inhibiting the Activation of Fibroblasts and Macrophages Pharmaceutics · 2025
    11. Spatiotemporal regulation of acute wound healing by the NLRP3 inflammasome: dual roles in macrophage-fibroblast chemotaxis and phenotype during wound repair Burns & Trauma · 2026
    12. 26SCS-Loaded SilMA/Col Composite Sponge with Well-Arranged Layers Promotes Angiogenesis-Based Diabetic Wound Repair by Mediating Macrophage Inflammatory Response 2024
    13. DcR3 reprograms macrophage plasticity to promote wound healing and hair regeneration Journal of Dermatological Science · 2026
    14. M-CSF-Stimulated CD11b+ Myeloid Cells Induce Alopecia Areata in C3H/HeJ Mice Research Square (Research Square) · 2021
    15. Tibial cortex transverse transport accelerates diabetic wound healing via systemic mobilization of non-classical monocytes Bone and Joint Research · 2026
    16. Engineering MMP9-Responsive Antioxidative Micelle-Hydrogel Dressings for Sequential Inflammatory Remodeling and Pro-Angiogenesis in Diabetic Wound Healing Precision medicine and engineering. · 2026
    17. All-in-one polysaccharide hydrogel with resistant vascular burst pressure and cooperative wound microenvironment regulation for fatal arterial hemorrhage and diabetic wound healing International journal of biological macromolecules · 2024
    18. Transcriptome analysis of frontal fibrosis alopecia revealed involvement of immune cells and ferroptosis Skin research and technology · 2024
    19. The influence of the antimicrobial topical ointment, Blastx, on the wound healing process in uninfected and Staphylococcus aureus infected wounds ThinkTech (Texas Tech University) · 2021
    20. 943 Temporal-spatial activation of Wnt-signaling within Type1 / Type 2 immunity during wound healing Journal of Investigative Dermatology · 2019
    21. Engineered Bilayer Hydrogel with Spatiotemporal Drug and Oxygen Delivery for Diabetic Wound Microenvironment Reprogramming Regenerative Biomaterials · 2025
    22. <em>Flammulina velutipes</em> polysaccharide boosts the anti-tumor immunity by reversing M1/M2 polarization through TLR4/NF-κB activation Food Science and Human Wellness · 2026
    23. All‐Natural Immunomodulatory Bioadhesive Hydrogel Promotes Angiogenesis and Diabetic Wound Healing by Regulating Macrophage Heterogeneity Advanced Science · 2023 · 254 citations
    24. Fibroblast Growth Factor-9 Enhances M2 Macrophage Differentiation and Attenuates Adverse Cardiac Remodeling in the Infarcted Diabetic Heart PLOS ONE · 2015 · 44 citations
    25. The impact of biomaterial characteristics on macrophage phenotypes in tissue engineering: a review Plastic and Aesthetic Research · 2025 · 6 citations
    26. The potential role of acetylcholine receptors in acne inversa (HS) pathogenesis Experimental dermatology · 2006 · 1 citations
    27. Weathering the Storm: Harnessing the Resolution of Inflammation to Limit COVID-19 Pathogenesis Frontiers in Immunology · 2022 · 17 citations
    28. Dynamic immunomodulatory nanoarchitectonics: Rewiring tissue regenerative microenvironment via intelligent regulation Nano Research · 2025
    29. Employee engagement: el reto de trabajar juntos E-Deusto: conocimiento para ir por delante · 2007
    30. Mechanical stretch induces hair regeneration through the alternative activation of macrophages Nature Communications · 2019 · 163 citations