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    Glossary Macrophage Polarization

    process where immune cells change roles based on signals

    Macrophage polarization refers to the process by which macrophages, a type of immune cell, change their functional state in response to different signals in their environment. They can adopt a pro-inflammatory state (M1) to fight infections or a healing state (M2) to repair tissues. This ability to switch roles is crucial for maintaining balance in the immune system and is important in conditions like infections, cancer, and autoimmune diseases.

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    1. Bioactive antiinflammatory antibacterial hemostatic citrate-based dressing with macrophage polarization regulation for accelerating wound healing and hair follicle neogenesis Bioactive Materials · 2020 · 61 citations
    2. Intrinsic ROS Drive Hair Follicle Cycle Progression by Modulating DNA Damage and Repair and Subsequently Hair Follicle Apoptosis and Macrophage Polarization Oxidative Medicine and Cellular Longevity · 2022 · 20 citations
    3. Macrophage Polarization: A Novel Target and Strategy for Pathological Scarring Tissue Engineering and Regenerative Medicine · 2024 · 4 citations
    4. CuATSM Enhances Wound Repair Without Scarring via Hippo/YAP Signalling Pathway to Reduce Ferroptosis and Macrophage Polarisation Journal of Cellular and Molecular Medicine · 2025 · 3 citations
    5. Human adipose tissue-derived small extracellular vesicles promote soft tissue repair through modulating M1-to-M2 polarization of macrophages Stem Cell Research & Therapy · 2023 · 2 citations
    6. Cedrol from Platycladus orientalis (L.) Franco regulates M1/M2 polarization of macrophages and promotes hair regeneration Journal of Ethnopharmacology · 2026
    7. Single-Cell RNA Sequencing Reveals Cellular and Transcriptional Changes Associated With M1 Macrophage Polarization in Hidradenitis Suppurativa Frontiers in medicine · 2021 · 22 citations
    8. ADM Scaffolds Generate a Pro-regenerative Microenvironment During Full-Thickness Cutaneous Wound Healing Through M2 Macrophage Polarization via Lamtor1 Frontiers in Physiology · 2018 · 17 citations
    9. Sustained Exosome‐Guided Macrophage Polarization Using Hydrolytically Degradable PEG Hydrogels for Cutaneous Wound Healing: Identification of Key Proteins and MiRNAs, and Sustained Release Formulation Small · 2022 · 40 citations
    10. Nanofiber-mediated sequential photothermal antibacteria and macrophage polarization for healing MRSA-infected diabetic wounds Journal of Nanobiotechnology · 2021 · 18 citations
    11. Dual-Action Icariin-Containing Thermosensitive Hydrogel for Wound Macrophage Polarization and Hair-Follicle Neogenesis Frontiers in Bioengineering and Biotechnology · 2022 · 6 citations
    12. Mitochondrial Complex I Activity Suppresses Inflammation and Enhances Bone Resorption by Shifting Macrophage-Osteoclast Polarization Cell Metabolism · 2014 · 222 citations
    13. Cepharanthine attenuates pulmonary fibrosis via modulating macrophage M2 polarization BMC Pulmonary Medicine · 2024 · 6 citations
    14. Abnormally activated wingless/integrated signaling modulates tumor-associated macrophage polarization and potentially promotes hepatocarcinoma cell growth World Journal of Gastroenterology · 2024 · 1 citations
    15. Effect of injectable calcium alginate-amelogenin hydrogel on macrophage polarization and promotion of jaw bone osteogenesis 2023
    16. Tannic acid-modified MoS 2 /silk fibroin hydrogel photothermal antibacterial synergistic macrophage M2 polarization regulation for the treatment of diabetic ulcers Materials Technology · 2026
    17. Xinyang tablet ameliorates sepsis-induced myocardial dysfunction by regulating Beclin-1 to mediate macrophage autophagy and M2 polarization through LncSICRNT1 targeting E3 ubiquitin ligase TRAF6 Chinese Medicine · 2023 · 6 citations
    18. Activation of Astrocytes <i>in Vitro</i> by Macrophages Polarized with Keratin Biomaterial Treatment Open journal of regenerative medicine · 2016 · 6 citations
    19. DcR3 reprograms macrophage plasticity to promote wound healing and hair regeneration Journal of Dermatological Science · 2026
    20. 26SCS-Loaded SilMA/Col Composite Sponge with Well-Arranged Layers Promotes Angiogenesis-Based Diabetic Wound Repair by Mediating Macrophage Inflammatory Response 2024
    21. The role of skin macrophages under conditions of stress and injury: ultraviolet irradiation and wound healing 2018
    22. Spatiotemporal regulation of acute wound healing by the NLRP3 inflammasome: dual roles in macrophage-fibroblast chemotaxis and phenotype during wound repair Burns & Trauma · 2026
    23. 3D bioprinting of engineered exosomes secreted from M2-polarized macrophages through immunomodulatory biomaterial promotes in vivo wound healing and angiogenesis Bioactive Materials · 2024 · 22 citations
    24. M2 Macrophage and Extracellular Matrix Genes Are Enriched in High‐Activity Lichen Planopilaris Dermatology Research and Practice · 2025
    25. Recent Advances in Bioengineered Scaffolds for Cutaneous Wound Healing Frontiers in Bioengineering and Biotechnology · 2022 · 81 citations
    26. An injectable bioactive dressing based on platelet-rich plasma and nanoclay: Sustained release of deferoxamine to accelerate chronic wound healing Acta Pharmaceutica Sinica B · 2022 · 62 citations
    27. Exploring nanobioceramics in wound healing as effective and economical alternatives Heliyon · 2024 · 40 citations
    28. Photoaging Skin Therapy with PRP and ADSC: A Comparative Study Stem Cells International · 2020 · 27 citations
    29. Biomembrane-Based Nanostructure- and Microstructure-Loaded Hydrogels for Promoting Chronic Wound Healing International Journal of Nanomedicine · 2023 · 24 citations
    30. Autonomous, Moisture‐Driven Flexible Electrogenerative Dressing for Enhanced Wound Healing Advanced Materials · 2025 · 23 citations