Exosomes: A Promising Strategy for Repair, Regeneration and Treatment of Skin Disorders

    June 2023 in “ Cells ”
    Mario Adrián Tienda-Vázquez, Juan Manuel Hanel, Elsa Margarita Márquez-Arteaga, Ana Paola Salgado-Álvarez, Christian Q. Scheckhuber, José Rafael Alanís-Gómez, Janette Ivone Espinoza-Silva, Manuel Ramos-Kuri, Fabiola Hernández‐Rosas, Elda M. Melchor-Martínez, Roberto Parra‐Saldívar
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    TLDR Exosomes could be a promising way to help repair skin and treat skin disorders.
    The review "Exosomes: A Promising Strategy for Repair, Regeneration and Treatment of Skin Disorders" discusses the potential of exosomes, nano-sized extracellular vesicles, in skin repair and regeneration. Exosomes can be isolated from various sources and contain bioactive compounds that have shown effectiveness as anti-inflammatory agents, inducers of macrophage polarization, and accelerators of skin repair and regeneration. They can transport biomolecules to recipient cells, influencing various cellular processes like gene expression, cell-to-cell signaling, immune response, and tissue repair. Exosomes derived from Mesenchymal Stem Cells (MSC-EXO) have been used in tissue regeneration and wound healing, and have shown potential in anti-aging, wound healing, and anti-inflammatory treatments. They have also been used in the treatment of atopic dermatitis and cutaneous wounds. Exosomes, particularly those in platelet-rich plasma (PRP), have shown promise in treating alopecia by promoting the survival of hair follicle stem cells. The document suggests that exosomes could be a promising strategy for skin repair and regeneration, and their potential in treating skin disorders warrants further investigation.
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