The Novel Mechanisms and Applications of Exosomes in Dermatology and Cutaneous Medical Aesthetics

April 2021 in “ Pharmacological research ”

Mingchen Xiong, Qi Zhang, Weijie Hu, Chongru Zhao, Wenchang Lv, Yi Yi, Yichen Wang, Huiping Tang, Min Wu, Yiping Wu

exosomes nanoscale vesicles biomolecules skin health cell communication skin development endogenic exosomes exogenous exosomes stem cells skin repair skin regeneration skin rejuvenation skin microenvironment dermatology cutaneous medical aesthetics

TLDR Exosomes can improve skin health and offer new treatments for skin repair and rejuvenation.

Exosomes, nanoscale vesicles derived from cells, played a significant role in skin health by carrying biomolecules that facilitate communication between cells. They were crucial in both physiological and pathological skin development. Endogenic exosomes influenced skin stability and function, while exogenous exosomes, such as those from stem cells, offered promising new treatments for skin repair, regeneration, and rejuvenation. Understanding the mechanisms of exosomes in the skin microenvironment had the potential to lead to innovative therapeutic methods in dermatology and cutaneous medical aesthetics.

View this study on sciencedirect.com →

Discuss this study in the Community →

Cited in this study

10 / 10 results

research Exosomes Derived from Human Dermal Papilla Cells Promote Hair Growth in Cultured Human Hair Follicles and Augment the Hair-Inductive Capacity of Cultured Dermal Papilla Spheres

58 citations , July 2019 in “Experimental Dermatology”

Exosomes from human skin cells can stimulate hair growth and could potentially be used for treating hair loss.

research A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth

192 citations , April 2019 in “ACS nano”

A new microneedle patch made from hair proteins helps regrow hair faster and better than current treatments.

research Skin Stem Cells, Their Niche, and Tissue Engineering Approach for Skin Regeneration

14 citations , January 2019 in “Advances in experimental medicine and biology”

Skin stem cells are promising for healing wounds and skin regeneration due to their accessibility and regenerative abilities.

research Biocompatible Nanoparticles and Vesicular Systems in Transdermal Drug Delivery for Various Skin Diseases

151 citations , January 2019 in “International Journal of Pharmaceutics”

Nanoparticles improve drug delivery through the skin but more research is needed on their long-term effects and skin penetration challenges.

research Exosomal MicroRNAs Derived from Dermal Papilla Cells Mediate Hair Follicle Stem Cell Proliferation and Differentiation

71 citations , January 2019 in “International journal of biological sciences”

Exosomes from dermal papilla cells help hair growth by making hair follicle stem cells multiply and change.

research The Medical and Psychosocial Associations of Alopecia: Recognizing Hair Loss as More Than a Cosmetic Concern

36 citations , November 2018 in “American Journal of Clinical Dermatology”

Alopecia is linked to various health and mental conditions, impacts life quality, and needs medical attention beyond its cosmetic effects.

research Skin Aging as a Mechanical Phenomenon: The Main Weak Links

41 citations , June 2018 in “Nutrition and healthy aging”

Skin aging is largely due to differences in stiffness and elasticity between skin layers, leading to wrinkles.

research Regulation of Hair Follicle Development by Exosomes Derived from Dermal Papilla Cells

87 citations , June 2018 in “Biochemical and Biophysical Research Communications”

Exosomes from dermal papilla cells can help grow hair and might treat hair loss.

research The Hair Follicle Enigma

25 citations , May 2017 in “Experimental Dermatology”

The document concludes that understanding hair follicles requires more research using computational methods and an integrative approach, considering the current limitations in hair treatment products.

research Mesenchymal Stem Cells from Adipose Tissue in Clinical Applications for Dermatological Indications and Skin Aging

132 citations , January 2017 in “International Journal of Molecular Sciences”

Fat-derived stem cells show promise for skin repair and reducing aging signs but need more research for consistent results.