Medicalized Aesthetic Uses of Exosomes and Cell Culture-Conditioned Media: Opening an Advanced Care Era for Biologically Inspired Cutaneous Prejuvenation and Rejuvenation

    September 2024 in “ Cosmetics
    Clara I. Rodrı́guez, Alexandre Porcello, Michèle Chemali, Wassim Raffoul, Cíntia Marques, Corinne Scaletta, Kelly Lourenço, Philippe Abdel-Sayed, Lee Ann Applegate, Fanny A. Pelissier Vatter, Alexis Laurent
    TLDR Exosomes and cell culture-conditioned media improve skin quality and reduce aging signs.
    The document reviews the potential of exosomes and cell culture-conditioned media in aesthetic medicine, particularly for skin rejuvenation and hair loss treatment. Exosomes, derived from stem cells, are noted for their regenerative capabilities, including improving skin brightness, elasticity, and reducing wrinkles. Clinical studies have shown promising results, especially in treating androgenetic alopecia with exosomes from human adipose-derived mesenchymal stem cells, leading to hair regrowth and repigmentation. Despite their potential, challenges such as lack of standardization, regulatory hurdles, and the need for precise terminology persist. The market for these treatments is expanding, with various formulations available, but further controlled trials and regulatory guidelines are necessary to ensure safety and efficacy.
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