TLDR The secretions of mesenchymal stem cells could be used for healing without using the cells themselves.
The document from 2017 reviews the potential of mesenchymal stem cell (MSC) secretome, including conditioned medium (CM) and exosomes, as a cell-free therapeutic strategy in regenerative medicine. It suggests that the benefits of MSC therapy are largely due to the bioactive factors they secrete, which can be used in place of direct cell transplantation. The secretome has been shown to be effective in various animal models for pathologies such as myocardial infarction, cerebral injury, and alopecia, and offers advantages in manufacturing, storage, handling, and shelf life. Human uterine cervical stem cells (hUCESCs) are highlighted as a promising source for secretome-derived products. The MSC secretome works through immunomodulation, anti-inflammatory activity, and anti-apoptotic effects, contributing to wound healing and tissue repair. The document also notes the need for regulatory guidelines to ensure the safety and efficacy of these cell-free products and suggests that modifying MSCs could enhance the therapeutic effects of their secretome.
135 citations,
December 2015 in “Expert Opinion on Biological Therapy” Exosomes could potentially enhance tissue repair and regeneration with lower rejection risk and easier production than live cell therapies.
83 citations,
March 2015 in “International Journal of Dermatology” ADSC-CM treatment improved hair density and thickness in women with hair loss, safely and effectively.
298 citations,
January 2014 in “BioMed Research International” Stem cell-derived conditioned medium shows promise for treating various medical conditions but requires standardized production and further validation.
134 citations,
January 2010 in “Biomedical research” Low oxygen conditions increase the hair-growing effects of substances from fat-derived stem cells by boosting growth factor release.
8 citations,
October 2022 in “Regenerative Therapy” New regenerative treatments for hair loss show promise but need more research for confirmation.
3 citations,
January 2023 in “Physiological Research” Conditioned media from mesenchymal stem cells show promise for tissue repair and disease treatment, but more research is needed on their safety and effectiveness.
7 citations,
January 2020 in “PubMed” Stem cell therapies show promise for treating hair loss, but more research is needed to understand their safety and effectiveness.
271 citations,
May 2019 in “Cells” The secretome from mesenchymal stem cells is a promising treatment that may repair tissue and avoid side effects of stem cell transplantation.
January 2023 in “Journal of Cosmetics, Dermatological Sciences and Applications” The hair growth serum Trichosera® was effective in increasing hair regrowth and density and reducing hair fall without significant side effects.
