Therapeutic Approach for Hair Growth and Regeneration Using Bioactive Formulation Containing Mesenchymal Stromal Cell-Derived Conditioned Medium

    January 2023 in “ Journal of Cosmetics, Dermatological Sciences and Applications ”
    Pawan Kumar Gupta, Sevitha Bhat, Suresh Kannan … Udaykumar Kolkundkar
    Studysummary In this study, researchers assessed the efficacy of Trichosera® hair serum, containing mesenchymal stromal cells conditioned media, among 40 healthy Indian volunteers, finding significant improvements in hair growth rate, hair density, scalp condition, and reduction in hair fall without notable adverse effects.
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    Research cited in this study 35

    1. Platelet-Rich Plasma for Hair Loss Springer eBooks · 2021
    2. The Effect of Conditioned Media From Human Adipocyte-Derived Mesenchymal Stem Cells on Androgenetic Alopecia After Nonablative Fractional Laser Treatment Dermatologic Surgery · 2020
    3. Promotion of Hair Growth by Conditioned Medium from Extracellular Matrix/Stromal Vascular Fraction Gel in C57BL/6 Mice Stem Cells International · 2020
    4. Migration Inhibitory Factor in Conditioned Medium from Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth Cells · 2020
    5. A Randomized, Double-Blind, Vehicle-Controlled Clinical Study of Hair Regeneration Using Adipose-Derived Stem Cell Constituent Extract in Androgenetic Alopecia Stem Cells Translational Medicine · 2020
    6. A Review of the Treatment of Male Pattern Hair Loss Expert Opinion on Pharmacotherapy · 2020
    7. Health Risks Associated with Long-Term Finasteride and Dutasteride Use: It's Time to Sound the Alarm The World Journal of Men's Health · 2020
    8. Sequential Scalp Assessment in Hair Regeneration Therapy Using an Adipose-Derived Stem Cell-Conditioned Medium Dermatologic Surgery · 2019
    9. Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development Cells · 2019
    10. Conditioned Media Derived from Mesenchymal Stem Cell Cultures: The Next Generation for Regenerative Medicine Journal of Tissue Engineering and Regenerative Medicine · 2019
    11. Platelet-Rich Plasma for Hair Loss Facial Plastic Surgery Clinics of North America · 2018
    12. Minoxidil Promotes Hair Growth Through Stimulation of Growth Factor Release from Adipose-Derived Stem Cells International Journal of Molecular Sciences · 2018
    13. The Basic Mechanism of Hair Growth Stimulation by Adipose-Derived Stem Cells and Their Secretory Factors Current Stem Cell Research & Therapy · 2017
    14. Platelet-Rich Plasma with Microneedling in Androgenetic Alopecia Along with Dermoscopic Pre- and Post-Treatment Evaluation Journal of Cosmetic Dermatology · 2017
    15. Up-To-Date Clinical Trials of Hair Regeneration Using Conditioned Media of Adipose-Derived Stem Cells in Male and Female Pattern Hair Loss Current stem cell research & therapy · 2017
    16. Androgenetic Alopecia: A Review Endocrine · 2017
    17. Clinical Use of Conditioned Media of Adipose Tissue-Derived Stem Cells in Female Pattern Hair Loss: A Retrospective Case Series Study International Journal of Dermatology · 2015
    18. Fibroblast Growth Factors Stimulate Hair Growth Through Beta-Catenin and Shh Expression in C57BL/6 Mice BioMed Research International · 2015
    19. Role of Platelet-Rich Plasma in Chronic Alopecia Areata: Our Centre Experience Indian Journal of Plastic Surgery · 2015
    20. The Dark Side of 5α-Reductase Inhibitors' Therapy: Sexual Dysfunction, High Gleason Grade Prostate Cancer, and Depression Korean Journal of Urology · 2014
    21. Prospect of Stem Cell Conditioned Medium in Regenerative Medicine BioMed Research International · 2014
    22. Female Pattern Alopecia: Current Perspectives International Journal of Women's Health · 2013
    23. Application of Mesenchymal Stem Cells Derived from Bone Marrow and Umbilical Cord in Human Hair Multiplication Journal of dermatological science · 2010
    24. Hair Growth Stimulated by Conditioned Medium of Adipose-Derived Stem Cells Is Enhanced by Hypoxia: Evidence of Increased Growth Factor Secretion Biomedical research · 2010
    25. Hair Growth Promoting Effects of Adipose Tissue-Derived Stem Cells Journal of Dermatological Science · 2009
    26. Comparing the Therapeutic Effects of Finasteride Gel and Tablet in Treatment of Androgenetic Alopecia Indian Journal of Dermatology, Venereology and Leprology · 2009
    27. Efficacy of 5% Minoxidil Versus Combined 5% Minoxidil and 0.01% Tretinoin for Male Pattern Hair Loss American Journal of Clinical Dermatology · 2007
    28. PDGF Isoforms Induce and Maintain Anagen Phase of Murine Hair Follicles Journal of Dermatological Science · 2006
    29. A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2002
    30. Comparative Efficacy of Various Treatment Regimens for Androgenetic Alopecia in Men Journal of Dermatology · 2002
    31. Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis Journal of Clinical Investigation · 2001
    32. Hepatocyte Growth Factor Activator Expressed in Hair Follicles Is Involved in In Vitro HGF-Dependent Hair Follicle Elongation Journal of Dermatological Science · 2001
    33. Teloptosis: A Turning Point in Hair Shedding Biorhythms Dermatology · 2001
    34. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    35. Minoxidil Stimulates Mouse Vibrissae Follicles in Organ Culture Journal of Investigative Dermatology · 1989

    Related research 7

    1. Complex Approach to the Treatment of Androgenetic Alopecia in Male Persons with a Poor Prognosis of the Disease Voennaâ medicina · 2022
    2. Deterioration of Scalp Environment by Exogenous Factors and Its Influence on Hair Growth Promoting Effect of Minoxidil The Pharmaceutical Society of Japan · 2020
    3. Scalp Psoriasiform Contact Dermatitis with Acute Telogen Effluvium Due to Topical Minoxidil Treatment Skin appendage disorders · 2015
    4. Possibilities And Limitations For Reversal Of Age-Related Hair Loss 2010
    5. Effect of Minoxidil on Hair Growth in Androgenic Alopecia in Women PubMed · 2002
    6. Topical Minoxidil in Male Pattern Baldness: Effects of Discontinuation of Treatment Journal of The American Academy of Dermatology · 1987
    7. Topical Minoxidil (3%) in Extensive Alopecia Areata, Including Long-Term Efficacy Journal of The American Academy of Dermatology · 1987