Therapeutic Approach for Hair Growth and Regeneration Using Bioactive Formulation Containing Mesenchymal Stromal Cell-Derived Conditioned Medium

January 2023 in “ Journal of Cosmetics, Dermatological Sciences and Applications ”

Pawan Kumar Gupta, Sevitha Bhat, Suresh Kannan, Raviraja N. Seetharam, Udaykumar Kolkundkar

mesenchymal stromal cells conditioned medium bone marrow-derived mesenchymal stromal cells growth factors cytokines hair growth serum Trichosera androgenetic alopecia hair regrowth hair density hair fall rate MSC CM BM-MSCs AGA

Studysummary In this study, researchers assessed the efficacy of Trichosera® hair serum, containing mesenchymal stromal cells conditioned media, among 40 healthy Indian volunteers, finding significant improvements in hair growth rate, hair density, scalp condition, and reduction in hair fall without notable adverse effects.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The research paper discusses a study conducted on 40 healthy Indian volunteers (10 males and 30 females) aged 18 to 65 years, testing the efficacy of a hair growth serum, Trichosera®, developed using conditioned media (CM) from adult human bone marrow-derived mesenchymal stromal cells (BM-MSCs). The CM contains growth factors and cytokines that promote hair growth. The study lasted for 24 weeks and showed that the use of MSC derived CM significantly increased human hair regrowth (18.66%) and hair density (11.54%), while reducing hair fall rate (48.65%). The serum was also found to be safe, with no significant adverse reactions. The study suggests that Trichosera® could be a promising alternative to current therapies for androgenetic alopecia (AGA). However, further studies with larger sample sizes are recommended.

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