Efficacy of 5% Minoxidil Versus Combined 5% Minoxidil and 0.01% Tretinoin for Male Pattern Hair Loss

The study compared the effectiveness of a combined solution of 5% minoxidil and 0.01% tretinoin with that of conventional 5% minoxidil in the treatment of androgenetic alopecia (AGA) in men. The study found that the application of the combined solution just once daily showed an equivalent treatment effect to that of 5% minoxidil applied twice daily in terms of changes in hair growth characteristics. Both groups demonstrated similar improvements in subjective global assessment of therapy by patients and the investigator. The occurrence of adverse effects such as pruritus or local irritation was similar in both groups. The study suggests that the combined solution could be a useful alternative for the treatment of AGA with a high rate of compliance.