Sequential Scalp Assessment in Hair Regeneration Therapy Using an Adipose-Derived Stem Cell-Conditioned Medium

September 2019 in “ Dermatologic Surgery ”

Keigo Narita, Hirotaro Fukuoka, Takuya Sekiyama, Hirotaka Suga, Kiyonori Harii

alopecia adipose-derived stem cell-conditioned medium ADSC-CM intradermal injections anagen hairs trans-epidermal water loss TEWL dermal thickness echogenicity hair follicles interfollicular scalp hair loss stem cell therapy growth phase hairs skin water loss skin thickness

TLDR Using a special stem cell formula on the scalp once a month for six months helped people with hair loss grow more hair.

In a study of 40 patients with alopecia, the application of adipose-derived stem cell-conditioned medium (ADSC-CM) through intradermal injections monthly for 6 months resulted in significant improvements in hair growth. The study observed a notable increase in hair density and the rate of anagen (growth phase) hairs. Additionally, there was a significant increase in trans-epidermal water loss (TEWL) at 4 and 6 months, although hydration and skin surface lipid levels did not change. Dermal thickness and echogenicity also increased significantly. These findings suggest that ADSC-CM could be a promising alternative treatment for alopecia, with potential regenerative effects on hair follicles and the interfollicular scalp.

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