Image

    Pathobiology of Chemotherapy-Induced Hair Loss

    January 2013 in “ The Lancet Oncology ”
    Ralf Paus, Iain S. Haslam, Andrey A. Sharov, Vladimir A. Botchkarev
    Studysummary This review discusses the pathobiology of chemotherapy-induced alopecia and highlights challenges in managing it, reporting no new clinical results and emphasizing the need for well-designed preclinical models to develop effective treatments.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on thelancet.com →
    Discuss this study in the Community →

    Research cited in this study 44

    1. Hair Shaft Abnormalities After Chemotherapy and Tamoxifen Therapy in Patients With Breast Cancer Evaluated by Optical Coherence Tomography British Journal of Dermatology · 2012
    2. Live Imaging of Stem Cell and Progeny Behavior in Physiological Hair-Follicle Regeneration Nature · 2012
    3. Chemotherapy-Induced Alopecia Journal of the American Academy of Dermatology · 2011
    4. Treatment of Chemotherapy-Induced Alopecia Dermatologic Therapy · 2011
    5. Hydroxyl Radical Mediates Cisplatin-Induced Apoptosis in Human Hair Follicle Dermal Papilla Cells and Keratinocytes Through Bcl-2-Dependent Mechanism APOPTOSIS · 2011
    6. A Neuroendocrinological Perspective on Human Hair Follicle Pigmentation Pigment Cell & Melanoma Research · 2010
    7. The Cell Biology of Human Hair Follicle Pigmentation Pigment cell & melanoma research · 2010
    8. The Pathogenesis of Primary Cicatricial Alopecias The American Journal of Pathology · 2010
    9. P53-Dependent Transcriptional Regulation of EDA2R and Its Involvement in Chemotherapy-Induced Hair Loss FEBS Letters · 2010
    10. The Mesenchymal Component of Hair Follicle Neogenesis: Background, Methods, and Molecular Characterization Experimental Dermatology · 2009
    11. Irreversible And Severe Alopecia Following Docetaxel Or Paclitaxel Cytotoxic Therapy For Breast Cancer British journal of dermatology/British journal of dermatology, Supplement · 2009
    12. Senile Hair Graying: H2O2-Mediated Oxidative Stress Affects Human Hair Color by Blunting Methionine Sulfoxide Repair The FASEB Journal · 2009
    13. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    14. Modulation of Chemotherapy-Induced Human Hair Follicle Damage by 17-Beta Estradiol and Prednisolone: Potential Stimulators of Normal Hair Regrowth by Dystrophic Catagen Promotion? Journal of Investigative Dermatology · 2008
    15. Prevention of Chemotherapy-Induced Alopecia in Rodent Models Cell stress & chaperones · 2008
    16. Nfatc1 Balances Quiescence and Proliferation of Skin Stem Cells Cell · 2008
    17. Melatonin in the Skin: Synthesis, Metabolism, and Functions Trends in Endocrinology and Metabolism · 2008
    18. Probing the Effects of Stress Mediators on the Human Hair Follicle American Journal of Pathology · 2007
    19. Human Hair Keratin Network And Curvature International Journal of Dermatology · 2007
    20. Six Cases of Permanent Alopecia After Various Conditioning Regimens Commonly Used in Hematopoietic Stem Cell Transplantation Bone marrow transplantation · 2007
    21. Dissecting the Impact of Chemotherapy on the Human Hair Follicle ˜The œAmerican journal of pathology · 2007
    22. Human Hair Follicles Are an Extrarenal Source and a Nonhematopoietic Target of Erythropoietin ˜The œFASEB journal · 2007
    23. Hair Loss Pattern Due to Chemotherapy-Induced Anagen Effluvium: A Cross-Sectional Observation Dermatology · 2007
    24. Protection Against Chemotherapy-Induced Alopecia Pharmaceutical Research · 2006
    25. Neuroimmunology of Stress: Skin Takes Center Stage Journal of Investigative Dermatology · 2006
    26. Chemotherapy Targets the Hair Follicle Vascular Network but Not the Stem Cells Journal of Investigative Dermatology · 2006
    27. Therapeutic Strategies for Treating Hair Loss Drug Discovery Today: Therapeutic Strategies · 2006
    28. Gene Expression Profiling Gets to the Root of Human Hair Follicle Stem Cells ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2005
    29. Hair Growth Inhibition by Psychoemotional Stress: A Mouse Model for Neural Mechanisms in Hair Growth Control Experimental Dermatology · 2005
    30. Zinc as an Ambivalent but Potent Modulator of Murine Hair Growth In Vivo: Preliminary Observations Experimental Dermatology · 2005
    31. The Role of Melatonin in Neuroectodermal-Mesodermal Interactions: The Hair Follicle Synthesizes Melatonin and Expresses Functional Melatonin Receptors ˜The œFASEB journal · 2005
    32. Atrophic Telogen Effluvium from Cytotoxic Drugs and a Randomized Controlled Trial to Investigate the Possible Protective Effect of Pretreatment with a Topical Vitamin D3 Analogue in Humans British Journal of Dermatology · 2005
    33. A Guide to Assessing Damage Response Pathways of the Hair Follicle: Lessons From Cyclophosphamide-Induced Alopecia in Mice Journal of Investigative Dermatology · 2005
    34. Human Hair Follicles Display a Functional Equivalent of the Hypothalamic-Pituitary-Adrenal (HPA) Axis and Synthesize Cortisol The FASEB Journal · 2005
    35. Mast Cell Deficient and Neurokinin-1 Receptor Knockout Mice Are Protected from Stress-Induced Hair Growth Inhibition Journal of Molecular Medicine · 2005
    36. Burden of Hair Loss: Stress and the Underestimated Psychosocial Impact of Telogen Effluvium and Androgenetic Alopecia Journal of Investigative Dermatology · 2004
    37. Topical Estrogen Accelerates Hair Regrowth in Mice After Chemotherapy-Induced Alopecia by Favoring the Dystrophic Catagen Response Pathway to Damage Journal of Investigative Dermatology · 2004
    38. Cutaneous Toxicities of Cancer Therapy Current opinion in oncology/Current opinion in oncology, with cancerlit · 2002
    39. Hair and Cancer Chemotherapy: Consequences and Nursing Care - A Literature Study European Journal of Cancer Care · 2001
    40. Overexpression of Bcl-2 Protects from Ultraviolet B-Induced Apoptosis but Promotes Hair Follicle Regression and Chemotherapy-Induced Alopecia ˜The œAmerican journal of pathology · 2000
    41. Do Hair Bulb Melanocytes Undergo Apoptosis During Hair Follicle Regression (Catagen)? ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1998
    42. Reduction of Intrafollicular Apoptosis in Chemotherapy-Induced Alopecia by Topical Calcitriol Analogs ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1998
    43. A Randomized Trial of Minoxidil in Chemotherapy-Induced Alopecia Journal of The American Academy of Dermatology · 1996
    44. The Protective Role of the Immunomodulator AS101 Against Chemotherapy-Induced Alopecia: Studies on Human and Animal Models International Journal of Cancer · 1996

    Related research 6

    1. What Can Complex Dietary Supplements Do for Hair Loss and How Can It Be Validly Measured: A Review Applied Sciences · 2020
    2. Blockade of S100A3 Activity Inhibits Murine Hair Growth Genetics and Molecular Research · 2015
    3. Electron Paramagnetic Resonance Spectroscopy for Investigating Murine Telogen Skin After Spontaneous or Depilation-Induced Hair Growth Journal of Dermatological Science · 2008
    4. Alopecia Journal of the Korean Medical Association · 2002
    5. Towards a Molecular Understanding of Hair Loss and Its Treatment Trends in Molecular Medicine · 2001
    6. Treatment of Hair Loss The New England Journal of Medicine · 1999