Reduction of Intrafollicular Apoptosis in Chemotherapy-Induced Alopecia by Topical Calcitriol Analogs

    October 1998 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Markus B. Schilli, Ralf Paus, Andreas Menrad
    TLDR Topical calcitriol-analogs can reduce hair loss caused by chemotherapy.
    The study demonstrated that topical application of calcitriol-analogs (1,25-dihydroxyvitamin D3, calcipotriol, and KH 1060) significantly reduced keratinocyte apoptosis in anagen hair follicles of C57 BL/6 mice induced by cyclophosphamide, although it did not completely prevent chemotherapy-induced alopecia. The maximal inhibition of apoptosis was observed on day 14 post-depilation. The findings suggested that calcitriol-analogs could modulate chemotherapy-induced apoptosis in hair follicles, providing a potential therapeutic approach to mitigate hair loss in cancer patients. The study involved at least 15 mice per group in 2-3 separate experiments and used a modified TUNEL method for detecting apoptotic cells.
    Discuss this study in the Community →

    Research cited in this study

    3 / 3 results

    Related Community Posts Join

    6 / 10 results

      community One year of progress (Fin, 1mg)

      in Is this regrowth?  281 upvotes 3 months ago
      The user started finasteride (1mg) a year ago for hair thinning, experiencing stabilization but not significant regrowth. Suggestions included adding minoxidil, microneedling, and considering a hair transplant for improved results.

      community Hair Loss Inflammation Prevention Stack

      in Research/Science  46 upvotes 1 week ago
      The conversation discusses a hair loss and scalp care routine involving ciclopirox shampoo, benzoyl peroxide, clindamycin gel, clobetasol propionate, and calcipotriol to manage seborrheic dermatitis, folliculitis, and inflammation. It also touches on the role of diet and other treatments like oral minoxidil and pioglitazone for scalp health.

      community Anyone used Topical Calcipotriol (cream) or VPA ( Valproic Acid)

      in Chat  8 upvotes 4 years ago
      The conversation discusses using topical Calcipotriol and Valproic Acid for hair loss, focusing on their mechanisms involving the VDR receptor and Wnt/beta-catenin pathway. Specific treatments mentioned are Minoxidil, Finasteride, and RU58841.

      community Using topical vitamin D, does it make sense?

      in Chat  6 upvotes 2 years ago
      Topical Calcipotriol (vitamin D derivative) may help with hair regrowth, especially for alopecia areata. The user wonders if adding classic vitamin D to lotions like Minoxidil could have a similar effect.

      community DHT Harms Scalp Microbiome: DHT Itch is REAL

      in Research/Science  407 upvotes 2 weeks ago
      Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

    Similar Research

    5 / 564 results