A Phase I Safety Study of Topical Calcitriol (BPM 31543) for the Prevention of Chemotherapy-Induced Alopecia

    May 2017 in “ Journal of Clinical Oncology ”
    Mario E. Lacouture, Jason A Konner, Viswanath Reddy Belum, Janice Stevens, Hedy Dion, Kathryn Ciccolini, Sarah Kitts, Ran Ye, Shobha Ravipaty, Viacheslav R Akmaev, Rangaprasad Sarangarajan, Joaquin Juan Jimenez, Niven R. Narain, Brian Berman, Shari Beth Goldfarb
    TLDR Topical calcitriol is safe for preventing hair loss during chemotherapy.
    The study investigated the safety of topical calcitriol (BPM 31543) for preventing chemotherapy-induced alopecia (CIA) in up to 31 women with breast cancer, gynecologic cancer, and sarcomas. Participants applied the treatment twice daily before and during taxane-based chemotherapy. Out of 28 enrolled patients, 21 were evaluable, and the study found that the treatment was safe and well-tolerated, with no severe adverse events or dose-limiting toxicities. Mild to moderate side effects included scalp pain and elevated vitamin D levels. A clinical response indicating potential efficacy was observed at all dose levels, but the maximum tolerated dose was not identified.
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      community Anyone used Topical Calcipotriol (cream) or VPA ( Valproic Acid)

      in Chat  7 upvotes 4 years ago
      The conversation discusses using topical Calcipotriol and Valproic Acid for hair loss, focusing on their mechanisms involving the VDR receptor and Wnt/beta-catenin pathway. Specific treatments mentioned are Minoxidil, Finasteride, and RU58841.

      community Using topical vitamin D, does it make sense?

      in Chat  5 upvotes 3 years ago
      Topical Calcipotriol (vitamin D derivative) may help with hair regrowth, especially for alopecia areata. The user wonders if adding classic vitamin D to lotions like Minoxidil could have a similar effect.

      community Hair Loss Inflammation Prevention Stack

      in Research/Science  49 upvotes 7 months ago
      The conversation discusses a hair loss and scalp care routine involving ciclopirox shampoo, benzoyl peroxide, clindamycin gel, clobetasol propionate, and calcipotriol to manage seborrheic dermatitis, folliculitis, and inflammation. It also touches on the role of diet and other treatments like oral minoxidil and pioglitazone for scalp health.

      community DHT Harms Scalp Microbiome: DHT Itch is REAL

      in Research/Science  413 upvotes 7 months ago
      Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

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