A Phase I Safety Study of Topical Calcitriol (BPM 31543) for the Prevention of Chemotherapy-Induced Alopecia

May 2017 in “ Journal of Clinical Oncology ”

Mario E. Lacouture, Jason A Konner, Viswanath Reddy Belum, Janice Stevens, Hedy Dion, Kathryn Ciccolini, Sarah Kitts, Ran Ye, Shobha Ravipaty, Viacheslav R Akmaev, Rangaprasad Sarangarajan, Joaquin Juan Jimenez, Niven R. Narain, Brian Berman, Shari Beth Goldfarb

calcitriol BPM 31543 chemotherapy-induced alopecia CIA taxane-based chemotherapy vitamin D

TLDR Topical calcitriol is safe for preventing hair loss during chemotherapy.

The study investigated the safety of topical calcitriol (BPM 31543) for preventing chemotherapy-induced alopecia (CIA) in up to 31 women with breast cancer, gynecologic cancer, and sarcomas. Participants applied the treatment twice daily before and during taxane-based chemotherapy. Out of 28 enrolled patients, 21 were evaluable, and the study found that the treatment was safe and well-tolerated, with no severe adverse events or dose-limiting toxicities. Mild to moderate side effects included scalp pain and elevated vitamin D levels. A clinical response indicating potential efficacy was observed at all dose levels, but the maximum tolerated dose was not identified.

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