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GlossaryTaxane-based chemotherapy

involves drugs that prevent cancer cell division

Taxane-based chemotherapy, also known as Taxane treatment, involves the use of drugs derived from the yew tree, such as paclitaxel and docetaxel, to treat various cancers. These drugs work by stabilizing microtubules in cancer cells, preventing them from dividing and leading to cell death. This type of chemotherapy is commonly used for breast, ovarian, and lung cancers, but it can also cause side effects like hair loss (alopecia) and neuropathy.

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research Madarosis: A Qualitative Study to Assess Perceptions and Experience of Australian Patients with Early Breast Cancer Treated with Taxane-Based Chemotherapy

11 citations, August 2017 in “Supportive care in cancer”

Madarosis (eyebrow and eyelash loss) significantly affects quality of life for breast cancer patients on taxane-based chemotherapy.

research Safety, Tolerability, and Pharmacokinetics of Topical Calcitriol Formulation for Treatment of Chemotherapy-Induced Alopecia in Patients Receiving Taxane-Based Regimen: Final Results

May 2019 in “Journal of clinical oncology”

Topical calcitriol was safe and well-tolerated for potential hair loss prevention in chemotherapy patients.

research Permanent Chemotherapy-Induced Alopecia in Patients with Breast Cancer: A 3-Year Prospective Cohort Study

59 citations, August 2018 in “The oncologist”

Some breast cancer patients still experience hair loss three years after chemotherapy, especially with taxane-based treatments.

research Management of Chemotherapy-Induced Alopecia With Scalp Cooling

25 citations, March 2018 in “Journal of oncology practice”

Scalp cooling is an effective and safe way to prevent hair loss from chemotherapy, with manageable side effects and low risk of scalp cancer.

research A Phase I Safety Study of Topical Calcitriol (BPM31543) for the Prevention of Chemotherapy-Induced Alopecia: Final Study Results

October 2018 in “Annals of oncology”

Topical calcitriol (BPM31543) is safe for preventing hair loss from chemotherapy and shows some effectiveness.

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