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GlossaryTaxanes

chemotherapy drugs that disrupt cell division by stabilizing microtubules

Taxanes are a class of chemotherapy drugs that work by disrupting the normal function of microtubules, which are essential for cell division. By stabilizing these structures, taxanes prevent cancer cells from dividing and growing, making them effective in treating various types of cancer. However, they can also cause side effects like hair loss (alopecia) due to their impact on rapidly dividing cells in the body.

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research Permanent Alopecia in Breast Cancer Patients: Role of Taxanes and Endocrine Therapies

2 citations, March 2021 in “Cutis”

Some breast cancer treatments, like taxanes, can cause long-term hair loss.

Gemcitabine in Combination with Vinorelbine in Elderly Patients with Anthracycline- and Taxane-Pretreated Metastatic Breast Cancer

research Gemcitabine in Combination with Vinorelbine in Elderly Patients with Anthracycline- and Taxane-Pretreated Metastatic Breast Cancer

9 citations, February 2012 in “Cancer Chemotherapy and Pharmacology”

The combination of gemcitabine and vinorelbine is effective and safe for treating elderly patients with advanced breast cancer previously treated with anthracyclines and taxanes.

research Use of Chemotherapy During Human Pregnancy

724 citations, April 2004 in “Lancet Oncology”

Chemotherapy in the first trimester of pregnancy is risky, but in the second and third trimesters, it's generally safe with careful drug selection and timing.

research Mucocutaneous Side Effects of Antineoplastic Chemotherapy

55 citations, November 2004 in “Expert opinion on drug safety”

Chemotherapy often causes hair loss, nail changes, and mouth issues, but these are usually manageable.

research Assessment of Quality of Life and Treatment Outcomes of Patients With Persistent Postchemotherapy Alopecia

43 citations, March 2019 in “JAMA Dermatology”

Hair regrowth treatments had modest benefits for patients with long-term hair loss after chemotherapy.

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