A Phase I Safety Study of Topical Calcitriol (BPM31543) for the Prevention of Chemotherapy-Induced Alopecia: Final Study Results

    October 2018 in “ Annals of oncology ”
    Mario E. Lacouture, Hedy Dion, Shobha Ravipaty, Viatcheslav R. Akmaev, Rangaprasad Sarangarajan, Joaquín J. Jiménez, Niven R. Narain, Brian Berman, Shari Goldfarb
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    TLDR Topical calcitriol (BPM31543) is safe for preventing hair loss from chemotherapy and shows some effectiveness.
    In a Phase 1 safety study from October 2018, topical calcitriol (BPM31543) was tested on 23 patients with breast cancer, gynecologic cancer, or sarcomas undergoing taxane-based chemotherapy to prevent chemotherapy-induced alopecia (CIA). Patients applied the treatment twice daily at escalating doses ranging from 5 to 80 µg/mL. The study found that BPM31543 was safe and well-tolerated, with no maximum tolerated dose (MTD) reached and no dose-limiting toxicity (DLT) observed. The most common treatment emergent adverse events (TEAEs) were fatigue, nausea, and peripheral sensory neuropathy, which were attributed to chemotherapy, while elevated vitamin D and rash were possibly related to the treatment. At week 7, 8 patients experienced less than 50% hair loss, and by week 15, 2 patients maintained this level of hair preservation. No significant changes in serum levels of calcitriol were detected. The results suggest some efficacy and support further research in Phase 2/3 trials. The study was funded and conducted by BERG, LLC, with several authors having affiliations with the company.
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      community Anyone used Topical Calcipotriol (cream) or VPA ( Valproic Acid)

      in Chat  8 upvotes 4 years ago
      The conversation discusses using topical Calcipotriol and Valproic Acid for hair loss, focusing on their mechanisms involving the VDR receptor and Wnt/beta-catenin pathway. Specific treatments mentioned are Minoxidil, Finasteride, and RU58841.

      community Using topical vitamin D, does it make sense?

      in Chat  6 upvotes 2 years ago
      Topical Calcipotriol (vitamin D derivative) may help with hair regrowth, especially for alopecia areata. The user wonders if adding classic vitamin D to lotions like Minoxidil could have a similar effect.

      community 8mg on oral finasteride. No results?

      in Progress Pictures  7 upvotes 1 year ago
      A user is experiencing worsening hair loss despite using 8mg of oral finasteride and is considering trying minoxidil or redoing blood work. They are concerned about thinning hair on the sides and back of their head.

      community One year of progress (Fin, 1mg)

      in Is this regrowth?  281 upvotes 2 months ago
      The user started finasteride (1mg) a year ago for hair thinning, experiencing stabilization but not significant regrowth. Suggestions included adding minoxidil, microneedling, and considering a hair transplant for improved results.

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