Prevention of Chemotherapy-Induced Alopecia in Rodent Models

The study investigated methods to prevent chemotherapy-induced alopecia in rodent models, finding that localized heat treatment or subcutaneous/intradermal injection of geldanamycin or 17AAG effectively induced a stress protein response in hair follicles, preventing hair loss without compromising chemotherapy efficacy. Experiments with young rats and mice showed significant hair retention in treated areas, with elevated Hsp70 levels correlating with protection. These results suggested potential pathways for developing human therapies, though further research was needed for clinical application.