Cutaneous Complications of Chemotherapeutic Agents

    November 1983 in “ Journal of The American Academy of Dermatology ”
    Anne K. Bronner, Antoinette F. Hood
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    TLDR Chemotherapy can cause skin problems like hair loss, mouth sores, and skin darkening, and recognizing these can affect treatment decisions.
    In 1983, Bronner and Hood reviewed the cutaneous complications from chemotherapeutic agents, noting common side effects like alopecia, stomatitis, and hyperpigmentation, as well as more unusual effects such as radiation enhancement and recall phenomena, photosensitivity, hypersensitivity reactions, and phlebitis or chemical cellulitis. They emphasized the importance for dermatologists to identify the responsible drug, as it can impact dosage and systemic toxicity. The review, based on literature and the authors' experiences, aimed to provide practical information for clinical situations. It detailed that stomatitis is dose-dependent and may require therapy cessation if severe, alopecia is reversible but psychologically devastating, and hyperpigmentation is variable and can affect nails, hair, mucosa, or skin. The document also discussed the interaction of chemotherapeutic agents with radiation, the importance of monitoring and managing these complications, and provided a classification of drugs with their associated cutaneous side effects.
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