Gene Expression Profiling Gets to the Root of Human Hair Follicle Stem Cells
December 2005
in “
The Journal of clinical investigation/The journal of clinical investigation
”
gene expression profiling hair follicle stem cells hair growth hair regeneration laser capture techniques bulge cells CD200 CD34 Keratin 15 melanocyte stem-cell fate immune cell reservoirs hair regeneration therapies skin biology gene profiling stem cells laser techniques melanocyte fate immune reservoirs hair therapies
TLDR Human hair follicle stem cells can be isolated using specific markers for potential therapeutic use.
The document from December 8, 2005, discussed the identification and characterization of gene expression profiles in human hair follicle stem cells to understand hair growth and regeneration mechanisms. Researchers used laser capture techniques to isolate bulge cells and identified specific markers, such as CD200, which is expressed in both human and mouse stem cells, unlike CD34, which is not expressed in human cells. The study highlighted differences between mouse and human hair follicle stem cells, suggesting potential therapeutic applications for treating hair loss and skin diseases. Key findings included the role of markers like Keratin 15 and CD34, the niche's influence on melanocyte stem-cell fate, and hair follicles as immune cell reservoirs, providing insights for hair regeneration therapies and skin biology.
