Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells

    December 2005 in “ ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation ”
    Manabu Ohyama
    TLDR Researchers successfully isolated and identified key markers of stem cell-enriched human hair follicle bulge cells.
    The study "Characterization and isolation of stem cell-enriched human hair follicle bulge cells" identified and isolated stem cells from the bulge region of human hair follicles using specific markers. Researchers found that these cells, marked by CD200, PHLDA1, follistatin, and frizzled homolog 1, had significant regenerative capabilities and high colony-forming efficiency. The study highlighted the bulge region as a crucial reservoir of quiescent keratinocyte stem cells (KSCs) and provided a systematic transcriptional profile of these cells. The findings suggested potential therapeutic strategies for hair loss and alopecia, emphasizing the role of CD200 in immune privilege and protection against inflammation.
    Discuss this study in the Community →

    Research cited in this study

    6 / 6 results

    Related Community Posts Join

    6 / 299 results

      community Clearing the air on how non-surgical treatments really work

       18 upvotes 5 years ago
      Treatments for hair loss, including finasteride, dutasteride, minoxidil, ketoconazole, microneedling, and low level laser light therapy, which aim to reduce DHT production, increase cell absorption and blood flow, and stimulate epidermal stem cells. It also stresses the importance of patience when using these treatments.
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 2 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Best Microneedle Lengths To Stimulate Stem Cells

      in Microneedling  18 upvotes 11 months ago
      Microneedling with needle lengths of 1.5mm to 2.5mm to stimulate hair follicle stem cells for potential hair growth. Using needles longer than 2.5mm is not recommended due to risk of puncturing veins in the scalp. A dermastamp is suggested over a roller.

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  43 upvotes 4 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

      community Hair theory Scar tissue and Verteporfin

      in Chat  25 upvotes 4 months ago
      A user suggests that deeper microneedling with Verteporfin injections might help regrow hair in areas with scar tissue, alongside a DHT blocker. Another user explains that hair loss might be due to reduced Wnt/β-Catenin signaling and suggests that treatments like Minoxidil, Finasteride, and microneedling could potentially reverse it.

    Similar Research

    5 / 1000+ results