Expansion Culture of Hair Follicle Stem Cells Through Uniform Aggregation in Microwell Array Devices

    February 2023 in “ ACS Biomaterials Science & Engineering ”
    Sugi Hirano, Tatsuto Kageyama, Maki Yamanouchi … Junji Fukuda
    Studysummary This study found that using a microwell array device to expand hair follicle stem cells in Matrigel significantly increased cell numbers and enhanced hair regeneration in mice.
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    Research cited in this study 21

    1. Expansion And Characterization Of Epithelial Stem Cells With Potential For Cyclical Hair Regeneration Scientific Reports · 2021
    2. Hair Follicle Germs Containing Vascular Endothelial Cells for Hair Regenerative Medicine Scientific Reports · 2021
    3. Effects of Platelet-Rich Plasma on In Vitro Hair Follicle Germ Preparation for Hair Regenerative Medicine Journal of Bioscience and Bioengineering · 2020
    4. Long-Term Expansion and Differentiation of Adult Murine Epidermal Stem Cells in 3D Organoid Cultures Proceedings of the National Academy of Sciences · 2019
    5. Preparation of Hair Beads and Hair Follicle Germs for Regenerative Medicine Biomaterials · 2019
    6. Tissue Engineering of Human Hair Follicles Using a Biomimetic Developmental Approach Nature Communications · 2018
    7. ROCK Inhibitor Y-27632 Maintains the Propagation and Characteristics of Hair Follicle Stem Cells PubMed · 2018
    8. Spontaneous Hair Follicle Germ Formation In Vitro, Enabling The Large-Scale Production Of HFGs For Regenerative Medicine Biomaterials · 2017
    9. Self-Organization Process in Newborn Skin Organoid Formation Inspires Strategy to Restore Hair Regeneration of Adult Cells Proceedings of the National Academy of Sciences of the United States of America · 2017
    10. Hair Follicle Stem Cell Cultures Reveal Self-Organizing Plasticity of Stem Cells and Their Progeny The EMBO Journal · 2016
    11. Mesenchymal–Epithelial Interactions During Hair Follicle Morphogenesis and Cycling Seminars in Cell & Developmental Biology · 2012
    12. Fully Functional Hair Follicle Regeneration Through the Rearrangement of Stem Cells and Their Niches Nature Communications · 2012
    13. Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation Cell stem cell · 2012
    14. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    15. Hair Follicle Regeneration Using Grafted Rodent and Human Cells Journal of Investigative Dermatology · 2007
    16. Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2005
    17. Organogenesis From Dissociated Cells: Generation of Mature Cycling Hair Follicles From Skin-Derived Cells Journal of Investigative Dermatology · 2005
    18. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    19. Noggin Is Required for Induction of the Hair Follicle Growth Phase in Postnatal Skin The FASEB Journal · 2001
    20. Inhibition of BMP Signaling Affects Growth and Differentiation in the Anagen Hair Follicle The EMBO Journal · 2000
    21. Changes in Fibronectin, Laminin, and Type IV Collagen Distribution Relate to Basement Membrane Restructuring During the Rat Vibrissa Follicle Hair Growth Cycle PubMed · 1992

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