Cells, Growth Factors and Biomaterials Used in Tissue Engineering for Hair Follicles Regeneration

November 2022 in “ Regenerative Therapy ”

Kailei Xu, Enxing Yu, Miaoben Wu, Peng Wei, Jun Yin

tissue engineering hair follicle regeneration dermal papilla cells DPCs skin-derived precursors SKPs hair follicle stem cells HFSCs Wnt SHH TGF-β collagen gelatin hyaluronic acid 3D cell culture co-transplantation hydrogels alopecia hair loss

TLDR Advancements in tissue engineering show promise for hair follicle regeneration to treat hair loss.

The document reviews advancements in tissue engineering for hair follicle (HF) regeneration, focusing on the use of various cells, growth factors, and biomaterials. Key cells like dermal papilla cells (DPCs), skin-derived precursors (SKPs), and hair follicle stem cells (HFSCs) are highlighted for their roles in HF regeneration. Growth factors such as Wnt, SHH, and TGF-β are crucial for this process. Biomaterials like collagen, gelatin, and hyaluronic acid support HF regeneration by mimicking the natural extracellular matrix. Techniques like 3D cell culture and co-transplantation with hydrogels have shown promise, although challenges remain in maintaining cell functionality and mimicking the natural HF microenvironment. The research indicates a promising future for clinical applications in treating alopecia and hair loss.

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