Identification of Key Genes Induced by Platelet-Rich Plasma in Human Dermal Papilla Cells Using Bioinformatics Methods

    December 2016 in “ Molecular Medicine Reports ”
    Haiyan Shen, Hanxiao Cheng, Haihua Chen, Jufang Zhang
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    TLDR Platelet-rich plasma may help hair follicle cells grow by affecting certain genes and pathways.
    The study investigated the impact of platelet-rich plasma (PRP) on human dermal papilla cells (HHDPCs), identifying 365 upregulated and 142 downregulated genes, as well as 178 differentially expressed long non-coding RNAs (lncRNAs), through RNA-seq data analysis. Key upregulated genes included CDK1 and PLK1, while MYC was notably downregulated. The analysis also highlighted transcription factors such as CEBPB, E2F1, and EGRI, which were enriched in cell cycle-related pathways. These findings suggest that PRP may promote the proliferation of HHDPCs by influencing these genes and pathways, indicating a potential role for PRP in hair follicle regeneration. Further research is necessary to explore the functional mechanisms of these genes in the context of PRP treatment and HHDPC proliferation.
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