Regulation of PDGF and PDGF Receptor in Cultured Dermal Papilla Cells and Follicular Keratinocytes of the Human Hair Follicle

    September 2003 in “ Experimental Dermatology ”
    H. Kamp, Christoph C. Geilen, Claudia Sommer, Ulrike Blume‐Peytavi
    TLDR PDGF signaling may play a role in hair growth cycle regulation.
    This study investigated the expression of platelet-derived growth factor (PDGF) and its receptors in dermal papilla cells (DPCs) and follicular keratinocytes (FKs) of human hair follicles. It was found that FKs expressed both types of PDGF receptors, while DPCs only expressed PDGF receptor β. FKs synthesized both PDGF-A and PDGF-B, whereas DPCs only expressed PDGF-A. The study also explored the impact of various cytokines on PDGF expression, revealing that catagen-inducing cytokines like IL-1β and IFN-γ significantly down-regulated PDGF factors, suggesting a potential role of PDGF signaling in catagen induction. Further research was needed to confirm this hypothesis in whole organ cultures.
    Discuss this study in the Community →

    Research cited in this study

    5 / 5 results

    Related Community Posts Join

    6 / 104 results

      community Comprehensive Microneedling Guide

      in Microneedling  289 upvotes 3 years ago
      Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

      community 1 month on minoxidil - progress pictures

      in Is this regrowth?  91 upvotes 5 months ago
      The user has been using finasteride for years and recently started using minoxidil foam, noticing some increased hair density and vellus hairs after one month. They report no scalp issues or side effects and also use a ketoconazole shampoo weekly.

      community Do you keep gains if you stop microneedling?

      in Microneedling  15 upvotes 2 months ago
      Stopping microneedling may result in losing hair gains, as it enhances the effectiveness of treatments like minoxidil. Combining microneedling with minoxidil and finasteride is more effective than using microneedling alone.

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  40 upvotes 5 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

    Similar Research

    5 / 1000+ results