Regulation of PDGF and PDGF Receptor in Cultured Dermal Papilla Cells and Follicular Keratinocytes of the Human Hair Follicle

September 2003 in “ Experimental Dermatology ”

H. Kamp, Christoph C. Geilen, Claudia Sommer, Ulrike Blume‐Peytavi

platelet-derived growth factor PDGF receptor dermal papilla cells follicular keratinocytes PDGF-A PDGF-B catagen cytokines IL-1β IFN-γ

TLDR PDGF signaling may play a role in hair growth cycle regulation.

The study investigated the expression patterns of platelet-derived growth factor (PDGF) and its receptors in dermal papilla cells (DPCs) and follicular keratinocytes (FKs) of human hair follicles. It was found that FKs expressed both types of PDGF receptors, while DPCs only expressed PDGF receptor β. Additionally, FKs synthesized both PDGF-A and PDGF-B, whereas DPCs only expressed PDGF-A. The study also explored the impact of various cytokines on PDGF expression, revealing that catagen-inducing cytokines like IL-1β and IFN-γ significantly down-regulated PDGF factors, suggesting a potential role of PDGF signaling in catagen induction. Further research was needed to confirm these findings in whole organ cultures.

View this study on onlinelibrary.wiley.com →

Discuss this study in the Community →

Research cited in this study

10 / 10 results

research Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis

1010 citations , August 2000 in “Cell”

Hair follicle stem cells can form both hair follicles and skin.

research Expression of Vascular Endothelial Growth Factor (VEGF) in Various Compartments of the Human Hair Follicle

105 citations , December 1998 in “Archives of Dermatological Research”

research Interleukin-1β Is Differentially Expressed by Human Dermal Papilla Cells in Response to PKC Activation and Is a Potent Inhibitor of Human Hair Follicle Growth in Organ Culture

38 citations , March 1997 in “Journal of interferon & cytokine research”

IL-1β inhibits human hair follicle growth.

Growth Factors and Cytokines in Hair Follicle Development and Cycling: Recent Insights from Animal Models and the Potentials for Clinical Therapy

research Growth Factors and Cytokines in Hair Follicle Development and Cycling: Recent Insights from Animal Models and the Potentials for Clinical Therapy

100 citations , November 1996 in “Molecular Medicine Today”

Growth factors and cytokines are important for hair growth and could potentially treat hair loss, but more research is needed to overcome challenges before they can be used in treatments.

research Whole Hair Follicle Culture

57 citations , October 1996 in “Dermatologic clinics”

HA-MNs with MXD effectively treat hair loss better than topical MXD with fewer side effects.

research Cytokines and Growth Factors Influence Hair Growth In Vitro: Possible Implications for the Pathogenesis and Treatment of Alopecia Areata

91 citations , March 1996 in “Archives of Dermatological Research”

Certain cytokines and growth factors can inhibit hair growth and may affect alopecia areata.

research Growth Factor and Growth Factor Receptor Localization in the Hair Follicle Bulge and Associated Tissue in Human Fetus

94 citations , March 1996 in “Journal of Investigative Dermatology”

research Culture of Hair Matrix and Follicular Keratinocytes

26 citations , July 1993 in “Journal of Investigative Dermatology”

research Hair Follicle Stem Cells: Their Location, Role in Hair Cycle, and Involvement in Skin Tumor Formation

85 citations , July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology”

research Soluble Factors From Human Hair Papilla Cells And Dermal Fibroblasts Dramatically Increase The Clonal Growth Of Outer Root Sheath Cells

62 citations , June 1993 in “Archives of Dermatological Research”

Related Community Posts Join

6 / 106 results

community Comprehensive Microneedling Guide

in Microneedling 292 upvotes 3 years ago

Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

community Growth factors, VEGF, And more,possible permanent cure for people with moderate hairloss?

in Research/Science 3 upvotes 1 year ago

The user discusses using dutasteride to stop hair loss and bimatoprost for regrowth. They plan to use VEGF with hydrogels for potentially permanent hair follicle improvement and suggest PRP as an alternative.

community 1 month on minoxidil - progress pictures

in Is this regrowth? 91 upvotes 6 months ago

The user has been using finasteride for years and recently started using minoxidil foam, noticing some increased hair density and vellus hairs after one month. They report no scalp issues or side effects and also use a ketoconazole shampoo weekly.

community Do you keep gains if you stop microneedling?

in Microneedling 15 upvotes 3 months ago

Stopping microneedling may result in losing hair gains, as it enhances the effectiveness of treatments like minoxidil. Combining microneedling with minoxidil and finasteride is more effective than using microneedling alone.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 42 upvotes 5 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

Similar Research

5 / 1000+ results

Anti-PDGF Receptor β Antibody-Conjugated Squarticles Loaded with Minoxidil for Alopecia Treatment by Targeting Hair Follicles and Dermal Papilla Cells

research Anti-PDGF Receptor β Antibody-Conjugated Squarticles Loaded with Minoxidil for Alopecia Treatment by Targeting Hair Follicles and Dermal Papilla Cells

17 citations , May 2015 in “Nanomedicine: Nanotechnology, Biology and Medicine”

Scientists created tiny particles loaded with a hair growth drug, minoxidil, that specifically target hair follicles and skin cells to potentially improve hair growth.

research Platelet-Derived Growth Factor Signaling Modulates Adult Hair Follicle Dermal Stem Cell Maintenance and Self-Renewal

37 citations , April 2017 in “npj Regenerative Medicine”

PDGF signaling is crucial for maintaining and renewing hair follicle stem cells, which could help treat hair loss.

research The Mechanism of Activated Platelet-Rich Plasma Supernatant Promotion of Hair Growth by Cultured Dermal Papilla Cells

14 citations , March 2019 in “Journal of Cosmetic Dermatology”

Activated platelet-rich plasma helps hair growth by boosting growth factors and cell growth pathways in hair cells.

research Ganoderma Lucidum Extract Attenuates Corticotropin-Releasing Hormone Induced Cellular Senescence in Human Hair Follicle Cells

April 2024 in “iScience”

Ganoderma lucidum extract may help treat stress-related hair loss.

research TGF-β2 Is Specifically Expressed in Human Dermal Papilla Cells and Modulates Hair Folliculogenesis

43 citations , March 2009 in “Journal of Cellular and Molecular Medicine”

TGF-β2 plays a key role in human hair growth and development.