Regulation of PDGF and PDGF Receptor in Cultured Dermal Papilla Cells and Follicular Keratinocytes of the Human Hair Follicle

    September 2003 in “ Experimental Dermatology ”
    H. Kamp, Christoph C. Geilen, Claudia Sommer, Ulrike Blume‐Peytavi
    TLDR PDGF signaling may play a role in hair growth cycle regulation.
    The study investigated the expression patterns of platelet-derived growth factor (PDGF) and its receptors in dermal papilla cells (DPCs) and follicular keratinocytes (FKs) of human hair follicles. It was found that FKs expressed both types of PDGF receptors, while DPCs only expressed PDGF receptor β. Additionally, FKs synthesized both PDGF-A and PDGF-B, whereas DPCs only expressed PDGF-A. The study also explored the impact of various cytokines on PDGF expression, revealing that catagen-inducing cytokines like IL-1β and IFN-γ significantly down-regulated PDGF factors, suggesting a potential role of PDGF signaling in catagen induction. Further research was needed to confirm these findings in whole organ cultures.
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