Regulation of PDGF and PDGF Receptor in Cultured Dermal Papilla Cells and Follicular Keratinocytes of the Human Hair Follicle

    September 2003 in “ Experimental Dermatology ”
    H. Kamp, Christoph C. Geilen, Claudia Sommer, Ulrike Blume‐Peytavi
    Studysummary In this study, researchers found that certain cytokines can significantly down-regulate PDGF expression in dermal papilla cells and follicular keratinocytes, indicating a potential link between PDGF signaling and catagen induction.
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    Research cited in this study 10

    1. Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis Cell · 2000
    2. Expression of Vascular Endothelial Growth Factor (VEGF) in Various Compartments of the Human Hair Follicle Archives of Dermatological Research · 1998
    3. Interleukin-1β Is Differentially Expressed by Human Dermal Papilla Cells in Response to PKC Activation and Is a Potent Inhibitor of Human Hair Follicle Growth in Organ Culture Journal of interferon & cytokine research · 1997
    4. Growth Factors and Cytokines in Hair Follicle Development and Cycling: Recent Insights from Animal Models and the Potentials for Clinical Therapy Molecular Medicine Today · 1996
    5. Whole Hair Follicle Culture Dermatologic clinics · 1996
    6. Cytokines and Growth Factors Influence Hair Growth In Vitro: Possible Implications for the Pathogenesis and Treatment of Alopecia Areata Archives of Dermatological Research · 1996
    7. Growth Factor and Growth Factor Receptor Localization in the Hair Follicle Bulge and Associated Tissue in Human Fetus Journal of Investigative Dermatology · 1996
    8. Culture of Hair Matrix and Follicular Keratinocytes Journal of Investigative Dermatology · 1993
    9. Hair Follicle Stem Cells: Their Location, Role in Hair Cycle, and Involvement in Skin Tumor Formation ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1993
    10. Soluble Factors From Human Hair Papilla Cells And Dermal Fibroblasts Dramatically Increase The Clonal Growth Of Outer Root Sheath Cells Archives of Dermatological Research · 1993