Ganoderma Lucidum Extract Attenuates Corticotropin-Releasing Hormone Induced Cellular Senescence in Human Hair Follicle Cells

April 2024 in “ iScience ”

Sunhyoung Lee, So Young Kim, Seunghee Lee, Sunhyae Jang, Sungjoo Hwang, Yong Wha Kwon, Jaehwan Choi, Oh Sang Kwon

Ganoderma lucidum corticotropin-releasing hormone cellular senescence human hair follicle cells reactive oxygen species anagen-inducing genes alkaline phosphatase MAPK pathway catagen cell proliferation markers stress-induced hair loss GL extract CRH ROS ALP MAPK

TLDR Ganoderma lucidum extract may help treat stress-related hair loss.

The study investigates the effects of Ganoderma lucidum (GL) extract on corticotropin-releasing hormone (CRH)-induced cellular senescence in human hair follicle cells (hHFCs). CRH was found to increase senescence markers and reactive oxygen species (ROS) while decreasing anagen-inducing genes and alkaline phosphatase (ALP) activity. GL extract counteracted these effects by restoring ALP activity, reducing ROS production, and preventing MAPK pathway activation. Additionally, GL extract delayed catagen entry and improved cell proliferation markers, suggesting its potential use in treating stress-induced hair loss.

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