Effects of Glucocorticoid on Human Dermal Papilla Cells In Vitro

    December 2012 in “ The Journal of Steroid Biochemistry and Molecular Biology ”
    Soon‐Jin Choi, A‐Ri Cho, Seong Jin Jo, Sungjoo Hwang, Kyu Han Kim, Ohsang Kwon
    TLDR Dexamethasone may cause hair loss by stopping cell growth.
    The study investigated the effects of the synthetic glucocorticoid dexamethasone (Dex) on human dermal papilla cells (hDPCs) in vitro, focusing on its impact on cell proliferation and growth factor expression. Dex treatment at a concentration of 1 μM significantly reduced the number of viable hDPCs and downregulated the expression of the Ki-67 protein, as well as growth factors VEGF and HGF. The findings suggested that Dex inhibited hair growth by inducing cell cycle arrest and decreasing cyclin D1 expression, highlighting the potential role of stress-induced glucocorticoids in hair loss.
    Discuss this study in the Community →

    Research cited in this study

    13 / 13 results

    Related Community Posts Join

    5 / 5 results

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  40 upvotes 5 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

      community We Need A Solution For The Inflammatory Response related To AGA

      in Research/Science  16 upvotes 1 year ago
      The conversation is about finding a solution for scalp inflammation related to AGA, with the user expressing frustration that Minoxidil and Finasteride do not address inflammation. The user has researched glucocorticoids and topical NSAIDs for reducing inflammation and seeks advice from specialists.

      community AA and Hirsutism but T levels are normal

      in Female  6 upvotes 4 years ago
      27-year-old female experiences aggressive hair thinning and hirsutism despite normal testosterone levels. Spironolactone and 2% minoxidil were ineffective; high DHEA sulfate levels may be the cause.

      community NootBro Recommendations… How Do We Feel

      in Research/Science  10 upvotes 1 year ago
      The conversation is about hair loss treatments, specifically a stack including topical Ashwagandha, Copper Peptide, Gotu Kola, Ketoconazole, and PDA. One user found Topical and Sub-Q GHK-CU effective.

    Related Research

    7 / 7 results