Glucocorticoid Effect on Hair Growth Initiation: A Reconsideration
January 1993
in “
Skin Pharmacology and Physiology
”
Studysummary In this study, topically applied glucocorticosteroids were found to block hair growth at the stage of hair formation, but not the initiation of hair growth, in a mouse model. Our plain-language summary of this paper — not a Tressless recommendation.
The study reexamined the effect of topically applied glucocorticosteroids on hair growth using a mouse model. It confirmed that these steroids block hair growth at the anagen initiation stage but do not prevent the induction of hair growth signals. Hair growth resumed once steroid application stopped, indicating that steroids block the expression of hair-forming genes rather than the initiation signals. This suggests that the system could be useful for identifying the signals or genes responsible for initiating hair growth.
