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research Hes1 regulates anagen initiation and hair follicle regeneration through modulation of hedgehog signaling

20 citations , November 2019 in “Stem Cells”

This study found that deleting the Hes1 gene disrupts hair regeneration by delaying anagen initiation and shortening the anagen phase, suggesting it's crucial for maintaining hair cycle homeostasis.

research 1326 Hes1 regulates anagen initiation and hair follicle regeneration through modulation of hedgehog signaling

April 2018 in “Journal of Investigative Dermatology”

This study found that the absence of Hes1 in hair follicles delays secondary hair germ activation and shortens the anagen phase, impacting HFSC self-renewal and long-term hair regeneration.

research Glucocorticoid Effect on Hair Growth Initiation: A Reconsideration

77 citations , January 1993 in “Skin Pharmacology and Physiology”

In this study, topically applied glucocorticosteroids were found to block hair growth at the stage of hair formation, but not the initiation of hair growth, in a mouse model.

research MOLECULAR AND CELLULAR BASIS OF EXOGEN AND ANAGEN INDUCTION

January 2007 in “Durham e-Theses (Durham University)”

This document details the usage policy for full-text reproduction from Durham E-Theses, providing guidelines for personal, educational, and non-commercial purposes without altering the text.

research Activin B Promotes Initiation and Development of Hair Follicles in Mice

5 citations , January 2013 in “Cells Tissues Organs”

This study found that activin B promotes the initiation and development of hair follicles in both cultured and neonatal mouse skin models.

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community Supplements for Health hair as for Gemini & Grok

1 upvotes 9 months ago

The conversation discusses various supplements and vitamins like Vitamin D3, K2, Biotin, Iron, Zinc, and B Vitamins for improving hair health. It also mentions a combination of Tocotrienols, Pycnogenol, Saw Palmetto, Pumpkin Seed Oil, Stinging Nettle, and Myricetin for stabilizing hair, with Saw Palmetto, Pygeum, and Stinging Nettle noted for thickening hair despite side effects.

community Has anyone done research on Absci's AI‑driven antibody platform? Seeking your thoughts!

4 upvotes 1 year ago

A user is interested in Absci's AI-driven antibody platform, ABS-201, for treating androgenetic alopecia, which shows promising preclinical results and potential for hair regrowth and pigmentation restoration. However, concerns are raised about the drug's development timeline and its advantages compared to existing treatments.

community How likely do you think it is for PP405 to come out?

in Research/Science 21 upvotes 11 months ago

PP405 is a potential new hair loss treatment that works through metabolic pathways rather than hormonal ones, with an estimated market release between late 2027 and 2029. Current alternatives to finasteride include minoxidil, pyralutamide, fluridil, and RU58841, with hair transplants also being a viable option.

community 57% increased chance of pattern hair loss independently associated with the consumption of sugary beverages in men (p<0.001).

297 upvotes 2 years ago

Sugary beverages increase the risk of pattern hair loss in men by 57%, and type 2 diabetes is linked to female pattern hair loss. Reducing sugar intake and using treatments like finasteride and minoxidil may help manage hair loss.

community I interviewed Kintor: GT20029 Clinical Trial Pictures. As well as KX826.

156 upvotes 1 year ago

GT20029 and KX826 are promising hair loss treatments, with GT20029 increasing hair count and KX826 showing significant results. KX826 may be a good alternative for those who can't use finasteride or dutasteride, though results vary.

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