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GlossaryCorticosteroids (Glucocorticoid)

hormones reducing inflammation and immune response, often prescribed for autoimmune diseases

Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex and are used in medicine to reduce inflammation and suppress the immune system. They are commonly prescribed for conditions like asthma, arthritis, and autoimmune diseases, and can be administered in various forms, including oral pills, topical creams, and injections.

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A Novel Point Mutation in the Ligand-Binding Domain of the Human Glucocorticoid Receptor Causing Generalized Glucocorticoid Resistance: The Importance of the C Terminus in Conferring Transactivational Activity

research A Novel Point Mutation in the Ligand-Binding Domain of the Human Glucocorticoid Receptor Causing Generalized Glucocorticoid Resistance: The Importance of the C Terminus in Conferring Transactivational Activity

91 citations, May 2005 in “The Journal of Clinical Endocrinology & Metabolism”

A new mutation in the human glucocorticoid receptor reduces its function and causes resistance to glucocorticoids.

research Large Doses of Glucocorticoid in the Treatment of Alopecia Areata

80 citations, November 1975 in “Acta dermato-venereologica”

Large doses of glucocorticoids are not suitable for general use in treating severe alopecia areata due to inconsistent results and risks.

research Glucocorticoid Effect on Hair Growth Initiation: A Reconsideration

77 citations, January 1993 in “Skin Pharmacology and Physiology”

Steroids stop hair growth temporarily but don't block the signals that start it.

Recent Advances in the Molecular Mechanisms Determining Tissue Sensitivity to Glucocorticoids: Novel Mutations, Circadian Rhythm, and Ligand-Induced Repression of the Human Glucocorticoid Receptor

research Recent Advances in the Molecular Mechanisms Determining Tissue Sensitivity to Glucocorticoids: Novel Mutations, Circadian Rhythm, and Ligand-Induced Repression of the Human Glucocorticoid Receptor

62 citations, August 2014 in “BMC Endocrine Disorders”

New findings explain how genetic changes, body clocks, and certain molecules affect tissue response to stress hormones.

research Modulation of Glucocorticoid Action and the Treatment of Type-2 Diabetes

54 citations, December 2007 in “Best Practice & Research Clinical Endocrinology & Metabolism”

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

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community We Need A Solution For The Inflammatory Response related To AGA

in Research/Science 16 upvotes 6 months ago

The conversation is about finding a solution for scalp inflammation related to AGA, with the user expressing frustration that Minoxidil and Finasteride do not address inflammation. The user has researched glucocorticoids and topical NSAIDs for reducing inflammation and seeks advice from specialists.

community AA and Hirsutism but T levels are normal

in Female 8 upvotes 4 years ago

27-year-old female experiences aggressive hair thinning and hirsutism despite normal testosterone levels. Spironolactone and 2% minoxidil were ineffective; high DHEA sulfate levels may be the cause.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 42 upvotes 5 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community No luck with meds, Check your Cortisol.

in Treatment 34 upvotes 7 months ago

Cortisol from stress can cause hair loss. Controlling cortisol levels improved the effectiveness of finasteride for hair regrowth.

community NootBro Recommendations… How Do We Feel

in Research/Science 9 upvotes 9 months ago

The conversation is about hair loss treatments, specifically a stack including topical Ashwagandha, Copper Peptide, Gotu Kola, Ketoconazole, and PDA. One user found Topical and Sub-Q GHK-CU effective.