Recent Advances in the Molecular Mechanisms Determining Tissue Sensitivity to Glucocorticoids: Novel Mutations, Circadian Rhythm, and Ligand-Induced Repression of the Human Glucocorticoid Receptor

    August 2014 in “ BMC Endocrine Disorders ”
    Nicolas C. Nicolaides, Evangelia Charmandari, George P. Chrousos, Tomoshige Kino
    Studysummary This review summarizes the recent advances in molecular mechanisms influencing tissue sensitivity to glucocorticoids, emphasizing novel mutations and new information on the glucocorticoid receptor's circadian rhythm and ligand-induced repression, but reports no new results.
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    Research cited in this study 3

    1. Primary Generalized Glucocorticoid Resistance And Hypersensitivity Hormone Research in Paediatrics · 2011
    2. A Novel Point Mutation in the Ligand-Binding Domain of the Human Glucocorticoid Receptor Causing Generalized Glucocorticoid Resistance: The Importance of the C Terminus in Conferring Transactivational Activity The Journal of Clinical Endocrinology & Metabolism · 2005
    3. Female Pseudohermaphroditism Caused by a Novel Homozygous Missense Mutation of the GR Gene ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2002